{"id":"W4238013362","doi":"10.21203/rs.3.rs-366981/v1","title":"Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"Blood Cancer UK; Cancer Research UK","keywords":"Somatic evolution in cancer; Lymphoblastic Leukemia; Dynamics (music); Biology; Cancer; Medicine; Immunology; Cancer research; Computational biology; Genetics; Leukemia; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004139821,0.0001162147,0.0002687899,0.0007759269,0.0003257425,0.001642999,0.0002093119,0.0002940659,0.006141761],"category_scores_gemma":[0.003667967,0.0002211364,0.0001996172,0.001007821,0.0001849219,0.0006650669,0.0004885775,0.0004581652,0.000809359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004830053,"about_ca_system_score_gemma":0.0003760929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001866145,"about_ca_topic_score_gemma":0.002176296,"domain_scores_codex":[0.9997399,0.00004256547,0.00001108863,0.00006429535,0.00007028475,0.00007173377],"domain_scores_gemma":[0.9990715,0.0003906797,0.0002188917,0.00009185812,0.00008114913,0.0001459718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001624599,0.0001342579,0.8135269,0.0002019648,0.0002592493,0.0006603643,0.001288255,0.003947599,0.02532265,0.02345995,0.009798927,0.1197753],"study_design_scores_gemma":[0.00009711163,0.0002011849,0.8951721,0.00008777146,0.0003682909,0.002146743,0.00267805,0.009910621,0.008660519,0.04444027,0.03619763,0.00003957094],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895424,0.001584817,0.000859573,0.0004832572,0.00003792519,0.00001118084,0.001354412,0.00006176071,0.006064526],"genre_scores_gemma":[0.9948204,0.00100566,0.0003158554,0.00006315531,0.00004954905,0.00001148903,0.0008709213,0.0000443426,0.002818648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006141761,"threshold_uncertainty_score":0.0205462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02969405159512867,"score_gpt":0.3738534803938197,"score_spread":0.344159428798691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}