{"id":"W4238119009","doi":"10.1002/ange.201505179","title":"A Modular, DNA‐Based Beacon for Single‐Step Fluorescence Detection of Antibodies and Other Proteins","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Associazione Italiana per la Ricerca sul Cancro; Bill and Melinda Gates Foundation","keywords":"Chemistry; Fluorophore; Molecular beacon; Nucleic acid; Fluorescence; DNA; Biophysics; Biochemistry; Combinatorial chemistry; Biology; Oligonucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004405996,0.0003865125,0.0002733693,0.0004108104,0.0001545948,0.0002284359,0.0006385971,0.0006122332,0.0009577729],"category_scores_gemma":[0.0003679124,0.0003286691,0.0002412073,0.0002094972,0.0003186429,0.0003028839,0.000329515,0.0006386729,0.0005789287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004090965,"about_ca_system_score_gemma":0.0003598732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002364271,"about_ca_topic_score_gemma":0.0003617386,"domain_scores_codex":[0.9997293,0.00003618438,0.00001047102,0.00007437154,0.0001102014,0.00003932009],"domain_scores_gemma":[0.9998711,0.00003058113,0.0000320182,0.000010154,0.00002271563,0.0000332729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002856385,0.00001699206,0.00005450073,0.00004895264,0.000003549552,0.00002452692,0.00001205372,0.0002257367,0.9944164,0.0003628114,0.000106215,0.004699794],"study_design_scores_gemma":[0.00003154672,0.000259034,0.000347903,0.000007128141,0.000008744991,0.0001858278,0.000004941603,0.003509297,0.991231,0.00012965,0.004270604,0.00001426437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5967197,0.006117195,0.3901303,0.0005703794,0.0003313658,0.0003013333,0.0005411291,0.002718041,0.002570677],"genre_scores_gemma":[0.8089095,0.001275111,0.1830428,0.0002689846,0.00005706105,0.0003055314,0.0005253461,0.0000735173,0.005542046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009577729,"threshold_uncertainty_score":0.003204107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02594680741050246,"score_gpt":0.2717323802049074,"score_spread":0.2457855727944049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}