{"id":"W4238119009","doi":"10.1002/ange.201505179","title":"A Modular, DNA‐Based Beacon for Single‐Step Fluorescence Detection of Antibodies and Other Proteins","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Associazione Italiana per la Ricerca sul Cancro; Bill and Melinda Gates Foundation","keywords":"Chemistry; Fluorophore; Molecular beacon; Nucleic acid; Fluorescence; DNA; Biophysics; Biochemistry; Combinatorial chemistry; Biology; Oligonucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128404,0.0001189511,0.0001474528,0.00003478389,0.00003504267,0.00001072079,0.0000589714,0.0001193451,2.059439e-7],"category_scores_gemma":[0.0001105631,0.0001018975,0.00006816674,0.00006217261,0.0001192779,0.000003863938,0.00003047098,0.0000310943,1.263282e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001200129,"about_ca_system_score_gemma":0.00002306086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001579018,"about_ca_topic_score_gemma":0.00003066946,"domain_scores_codex":[0.999393,0.0000128935,0.0001371552,0.000241195,0.00008233866,0.0001334312],"domain_scores_gemma":[0.9995024,0.000007259157,0.0000973069,0.0001921697,0.0001478187,0.00005306721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001190947,0.00004727509,0.00027188,0.00003848566,0.00002533644,4.107598e-7,0.00001425852,0.000001178089,0.997165,0.000002178623,0.00008144511,0.002233516],"study_design_scores_gemma":[0.0004181668,0.0003783976,0.00004563365,0.00003099659,0.00003407304,0.000004957745,0.00004311193,0.00008315309,0.9926673,0.00006607734,0.00609435,0.0001338491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827085,0.0005348927,0.01598618,0.0000677294,0.0000267432,0.0002912875,0.00004146119,0.00003528622,0.0003079731],"genre_scores_gemma":[0.9829805,0.00001907403,0.01667091,0.00009203727,0.0000845742,0.00001927573,0.00003451104,0.00001583151,0.00008332154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006012905,"threshold_uncertainty_score":0.415526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02594680741050246,"score_gpt":0.2717323802049074,"score_spread":0.2457855727944049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}