{"id":"W4238172020","doi":"10.1002/ange.201810760","title":"Transition‐Metal‐Free [4+3]‐Cycloaddition of <i>ortho</i>‐Quinone Methides and Isomünchnones: Catalytic and Diastereoselective Assembly of Oxa‐bridged Oxazocine Scaffolds","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Synthesis of Indole Derivatives","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft","keywords":"Cycloaddition; Chemistry; Catalysis; Diastereomer; Rhodium; Yield (engineering); Quinone; Stereochemistry; Combinatorial chemistry; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040643,0.0003388142,0.0001034182,0.0001006634,0.00009676404,0.0001645654,0.0002415218,0.000146948,0.001888244],"category_scores_gemma":[0.00007803204,0.0001228006,0.0001211093,0.00006162767,0.0001625735,0.0001878872,0.000158345,0.0001858756,0.0003391818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002160075,"about_ca_system_score_gemma":0.0001394487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003497482,"about_ca_topic_score_gemma":0.001366785,"domain_scores_codex":[0.9999316,0.00001255653,0.00000404695,0.00001060811,0.00001468637,0.00002653269],"domain_scores_gemma":[0.9999605,0.000006305946,0.00001344826,0.000006186561,0.000004594179,0.000008876777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007679773,0.00002763466,0.0001052842,0.0000820197,0.000005544665,0.000146635,0.00005747837,0.0002977462,0.9943448,0.0009817255,0.0001696264,0.003704702],"study_design_scores_gemma":[0.00001251676,0.0002386381,0.0008539144,0.000003630841,0.000006886275,0.0001294886,0.00001290482,0.0006431368,0.9944105,0.0001053243,0.003574765,0.00000833198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690005,0.0007661554,0.01263334,0.00009373842,0.00006866708,0.00006088749,0.0001850535,0.0002420878,0.01694965],"genre_scores_gemma":[0.9949058,0.0002384379,0.002512565,0.00001424807,0.000006241949,0.00001388286,0.00007362256,0.00001777215,0.002217353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888244,"threshold_uncertainty_score":0.006316781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386857035321532,"score_gpt":0.2351298341963679,"score_spread":0.2212612638431526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}