{"id":"W4238255813","doi":"10.1002/ange.201806966","title":"Site‐Selective, Late‐Stage C−H <sup>18</sup>F‐Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; BC Cancer Agency; TRIUMF","funders":"Canadian Cancer Society Research Institute; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; F. Hoffmann-La Roche","keywords":"Positron emission tomography; Peptide; Molecular imaging; Chemistry; Pet imaging; Peptide synthesis; Combinatorial chemistry; Radiochemistry; Nuclear medicine; Biochemistry; In vivo; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004734043,0.0004129896,0.0003166808,0.0001583461,0.0005001523,0.00004936646,0.0003392195,0.0004016407,0.001780223],"category_scores_gemma":[0.0003276877,0.0004187331,0.0001966219,0.0005078907,0.0002628971,0.0001833928,0.0001136618,0.0007368631,0.0001195373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002628479,"about_ca_system_score_gemma":0.00008547321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002662774,"about_ca_topic_score_gemma":0.000004953586,"domain_scores_codex":[0.9979234,0.00008917394,0.0003827639,0.0006869127,0.0002336301,0.0006840912],"domain_scores_gemma":[0.9984158,0.0004271317,0.0001949898,0.0003730501,0.0003379083,0.0002511109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007439011,0.0002530442,0.007022362,0.0001405842,0.0001255634,0.00001276975,0.0006664147,0.00005340946,0.9405317,0.00002761211,0.04833763,0.002085055],"study_design_scores_gemma":[0.002141714,0.0001958085,0.0007396212,0.00005419126,0.0001191633,0.00001124707,0.00007823644,0.001197018,0.9063638,0.0002448402,0.08844113,0.0004132382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779463,0.0002491964,0.000117926,0.0008841704,0.0003706764,0.0008002872,0.0001641974,0.0003927124,0.01907453],"genre_scores_gemma":[0.9869505,0.00004094187,0.000536589,0.0009771551,0.001295006,0.0001696172,0.0002468806,0.00008436705,0.009698982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0401035,"threshold_uncertainty_score":0.9998264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05076904509622088,"score_gpt":0.374253424441432,"score_spread":0.3234843793452111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}