{"id":"W4238275106","doi":"10.1158/1538-7445.am2019-4531","title":"Abstract 4531: SWATH-MS profiling identifies prognostic factors for progression-free survival (PFS) In INTEGRATE - A randomized phase II double-blind placebo-controlled study of regorafenib in refractory advanced oesophagogastric cancer (AOGC) - A study by the Australasian Gastrointestinal Trials Group (AGITG)","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University Health Centre","funders":"","keywords":"Hazard ratio; Medicine; Internal medicine; Regorafenib; Quartile; Placebo; Oncology; Proportional hazards model; Confidence interval; Cancer; Randomized controlled trial; Progression-free survival; Colorectal cancer; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001094547,0.000486182,0.0007423536,0.000332505,0.0002807618,0.0006318616,0.0002508027,0.0003834584,0.002878395],"category_scores_gemma":[0.000774268,0.0002356731,0.0005730806,0.0004083673,0.0003758915,0.0002676673,0.0002898047,0.0006972862,0.000414714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002581422,"about_ca_system_score_gemma":0.0004855923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002647288,"about_ca_topic_score_gemma":0.0004274962,"domain_scores_codex":[0.9997009,0.00009227099,0.00002435647,0.00008605023,0.00006734139,0.00002912087],"domain_scores_gemma":[0.9996405,0.00006307779,0.0001428272,0.00004208359,0.00004197818,0.00006953972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2680366,0.006258052,0.1837983,0.0009981177,0.002154315,0.000387832,0.0002565242,0.001545277,0.4226489,0.0002974779,0.006635728,0.106983],"study_design_scores_gemma":[0.05078403,0.0977691,0.7219873,0.0000894574,0.003233139,0.002563348,0.0001731665,0.005305898,0.1065806,0.0005211742,0.01089959,0.00009318968],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959134,0.00105424,0.0006533093,0.0001159837,0.00002349021,0.0002163389,0.00156532,0.00004393691,0.000413888],"genre_scores_gemma":[0.990966,0.0004707855,0.002366356,0.000257344,0.00007097699,0.0003799729,0.004567986,0.00001852048,0.0009020373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002878395,"threshold_uncertainty_score":0.00962919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08155113361549109,"score_gpt":0.4343861055570113,"score_spread":0.3528349719415202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}