{"id":"W4238284361","doi":"10.1002/ange.201909308","title":"High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates","year":2019,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Organoboron and organosilicon chemistry","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Pfizer","keywords":"Stereocenter; Enantioselective synthesis; Chemistry; Borylation; Alkyl; Ligand (biochemistry); Aryl; Chemoselectivity; Combinatorial chemistry; Conjugate; Boronic acid; Stereochemistry; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001810138,0.000361284,0.0004416577,0.00004838784,0.0001515387,0.0001160105,0.0007105508,0.0002443352,0.001708213],"category_scores_gemma":[0.000179435,0.0002818824,0.0001467525,0.0002758716,0.0001635313,0.0003209698,0.0003282756,0.0002814319,0.0000701305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008916611,"about_ca_system_score_gemma":0.0000995705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002307746,"about_ca_topic_score_gemma":0.00002523855,"domain_scores_codex":[0.9980351,0.00002000915,0.0004690629,0.0005774942,0.0004079272,0.0004904104],"domain_scores_gemma":[0.9983857,0.0003459786,0.0002351606,0.0006704482,0.0002081175,0.000154547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078403,0.00007660906,0.01898349,0.0002230027,0.0001353822,0.000004877086,0.0004577395,0.00005793051,0.978043,0.00008185395,0.001105855,0.000722377],"study_design_scores_gemma":[0.0007294437,0.00002655173,0.004584746,0.0002085925,0.00008640189,0.00001082833,0.0003969964,0.00002064338,0.991361,0.0001744687,0.00203752,0.0003628605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913647,0.0003733359,0.00007961454,0.00149491,0.000130691,0.0002237459,0.0001174778,0.0001355929,0.006079889],"genre_scores_gemma":[0.9978724,0.0001095642,0.0003177341,0.0004332458,0.0002194415,0.00003095061,0.00008292555,0.00006558462,0.0008681527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01439875,"threshold_uncertainty_score":0.9999633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009902444930648275,"score_gpt":0.23951427505323,"score_spread":0.2296118301225817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}