{"id":"W4238284361","doi":"10.1002/ange.201909308","title":"High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates","year":2019,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Organoboron and organosilicon chemistry","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Pfizer","keywords":"Stereocenter; Enantioselective synthesis; Chemistry; Borylation; Alkyl; Ligand (biochemistry); Aryl; Chemoselectivity; Combinatorial chemistry; Conjugate; Boronic acid; Stereochemistry; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003263906,0.0005477293,0.0003305533,0.0003840709,0.0001687893,0.0005418381,0.000314355,0.0002289732,0.001948653],"category_scores_gemma":[0.000193337,0.0001658367,0.0002102133,0.0002978105,0.0002420611,0.0002856952,0.0003738953,0.0003961441,0.0009104698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003460715,"about_ca_system_score_gemma":0.0003226521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000567244,"about_ca_topic_score_gemma":0.001429974,"domain_scores_codex":[0.9997295,0.00004061436,0.00001354009,0.00005570373,0.00008823934,0.00007245838],"domain_scores_gemma":[0.9999158,0.00001903285,0.00001775504,0.00001407316,0.00001684965,0.00001653901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001471029,0.00006394908,0.0002639866,0.00005695902,0.00001016098,0.00009923318,0.00002161982,0.0004635432,0.9902541,0.0004371967,0.0003016565,0.007880426],"study_design_scores_gemma":[0.00001473752,0.0001588464,0.0003438499,0.000004409034,0.000006474232,0.00007896154,0.00001251397,0.001089327,0.9961554,0.00005714184,0.002071699,0.000006486561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9355649,0.002551849,0.04120595,0.0003755082,0.00007250792,0.0002521279,0.00212041,0.0009519131,0.01690477],"genre_scores_gemma":[0.9807664,0.0013107,0.01238029,0.00006484138,0.000009607033,0.00007928425,0.001018934,0.00005205076,0.004318006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001948653,"threshold_uncertainty_score":0.0065189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009902444930648275,"score_gpt":0.23951427505323,"score_spread":0.2296118301225817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}