{"id":"W4238514467","doi":"10.1200/jco.2019.37.15_suppl.e15753","title":"Comprehensive genomic analysis of metastatic pancreatic ductal adenocarcinoma (mPDAC) reveals a significant proportion of clinical actionable aberrations.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency; Vancouver Coastal Health Research Institute; Vancouver Coastal Health; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Vancouver General Hospital; Pancreas Centre (Canada); Canada's Michael Smith Genome Sciences Centre; Genome British Columbia","funders":"","keywords":"Medicine; FOLFIRINOX; KRAS; Oncology; Sunitinib; Internal medicine; Pancreatic cancer; Germline mutation; PARP inhibitor; Cancer; Cancer research; Mutation; Genetics; Colorectal cancer; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082543,0.00022579,0.0002691266,0.0009906268,0.0002331745,0.0003713739,0.0001980038,0.0003077853,0.002470639],"category_scores_gemma":[0.000575016,0.0001290723,0.0001810405,0.000865703,0.0001820577,0.0001432335,0.000454994,0.0002700077,0.0005354957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002641741,"about_ca_system_score_gemma":0.0001989239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009344549,"about_ca_topic_score_gemma":0.002807709,"domain_scores_codex":[0.9997908,0.0000216088,0.000016068,0.00006999054,0.00007058786,0.00003091296],"domain_scores_gemma":[0.9997749,0.00004792052,0.00006097342,0.00003510074,0.00003750121,0.00004353569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001375461,0.00009303075,0.5182235,0.0004111516,0.0002965986,0.005075808,0.000227269,0.0007523102,0.3829257,0.0003184045,0.00358735,0.0867133],"study_design_scores_gemma":[0.00003491869,0.0003244388,0.9497483,0.00003656775,0.000135535,0.015134,0.0001889304,0.0005846964,0.02422123,0.000326629,0.009256289,0.000008459701],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879338,0.002302921,0.001199562,0.0002256282,0.0000108211,0.00003560175,0.006481863,0.0001109384,0.001698917],"genre_scores_gemma":[0.9902071,0.0008652369,0.001539631,0.0001275081,0.000008612084,0.00002463701,0.006498415,0.00001947452,0.0007092558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002470639,"threshold_uncertainty_score":0.008265138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09350536448579719,"score_gpt":0.4297020608567672,"score_spread":0.3361966963709699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}