{"id":"W4238575387","doi":"10.1093/annonc/mdy425.042","title":"KEYNOTE-189 study of pembrolizumab (pembro) plus pemetrexed (pem) and platinum vs placebo plus pem and platinum for untreated, metastatic, nonsquamous NSCLC: Does choice of platinum affect outcomes?","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Santé Montérégie","funders":"","keywords":"Medicine; Placebo; Carboplatin; Nausea; Internal medicine; Lung cancer; Pembrolizumab; Oncology; Cisplatin; Chemotherapy; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002092423,0.00135203,0.003070632,0.0002982213,0.0003993265,0.001251837,0.001241763,0.001984495,0.01063138],"category_scores_gemma":[0.002513036,0.0008341538,0.004996708,0.0003652835,0.0008895756,0.001390275,0.0005912863,0.005426444,0.001696313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008435891,"about_ca_system_score_gemma":0.001029472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356076,"about_ca_topic_score_gemma":0.002654527,"domain_scores_codex":[0.9986591,0.0007968761,0.0000791751,0.000199143,0.00008035285,0.0001853302],"domain_scores_gemma":[0.9985833,0.0005697493,0.0002521949,0.0001543215,0.00006759239,0.0003727618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9884663,0.002108541,0.0006500673,0.0002058685,0.001895765,0.00002381762,0.00001475863,0.0001252452,0.0008706942,0.00008496238,0.0005485291,0.005005518],"study_design_scores_gemma":[0.8742971,0.1122756,0.007259549,0.00005202186,0.00342605,0.0000345845,0.00003448767,0.0003549939,0.0004869647,0.0002708217,0.001483645,0.00002424022],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978741,0.006209475,0.0007737911,0.001847238,0.002311771,0.001684539,0.003584415,0.00008354179,0.004764356],"genre_scores_gemma":[0.9823392,0.002506662,0.001017168,0.002027011,0.00160898,0.001341369,0.002379079,0.0000331477,0.006747266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01063138,"threshold_uncertainty_score":0.0355655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07705669747757675,"score_gpt":0.3994233666933724,"score_spread":0.3223666692157957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}