{"id":"W4238609105","doi":"10.1172/jci0215420","title":"Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":378,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada)","funders":"U.S. Public Health Service; American Heart Association","keywords":"Lactosylceramide; Caveolae; Golgi apparatus; Sphingolipid; Cell biology; Rab; Lipid raft; Sphingomyelin; Ceramide; Biology; Pinocytosis; Vesicular transport protein; Clathrin; Glycosphingolipid; Endocytosis; Chemistry; Vesicle; Biochemistry; Signal transduction; Receptor; Glycolipid; Cholesterol; GTPase; Membrane; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001246586,0.0001354267,0.000436411,0.00008510009,0.00002178486,0.000009765596,0.0001370975,0.0002462259,0.000032617],"category_scores_gemma":[0.0002202785,0.0001206742,0.0002305164,0.0001033612,0.0001771764,0.00002034107,0.00001038902,0.0003159953,0.00000114222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001002371,"about_ca_system_score_gemma":0.00006139184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002836206,"about_ca_topic_score_gemma":0.0001141496,"domain_scores_codex":[0.9977968,0.0001468254,0.001480587,0.0001942994,0.000238261,0.000143218],"domain_scores_gemma":[0.9987399,0.00005564286,0.0007706153,0.0001310905,0.000139232,0.0001635142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005614061,0.0002155104,0.1853046,0.0001160279,0.00008190642,0.00002865599,0.0008080642,0.0004023124,0.8073258,0.00002363765,0.0001399881,0.004992048],"study_design_scores_gemma":[0.011896,0.003706035,0.1890415,0.001034255,0.0003049813,0.0001235181,0.000228849,0.006738679,0.7655457,0.0004800807,0.02022753,0.0006728981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946216,0.0005760773,0.003830781,0.0002066749,0.0005016611,0.0001668861,0.000003897617,0.000003775364,0.00008863844],"genre_scores_gemma":[0.9969831,0.001223749,0.0009801746,0.0001480116,0.0005065561,0.000002176211,0.00005419162,0.00001350742,0.0000884967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04178017,"threshold_uncertainty_score":0.4920952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03484175087733286,"score_gpt":0.2877694204625575,"score_spread":0.2529276695852246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}