{"id":"W4238609105","doi":"10.1172/jci0215420","title":"Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":378,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada)","funders":"U.S. Public Health Service; American Heart Association","keywords":"Lactosylceramide; Caveolae; Golgi apparatus; Sphingolipid; Cell biology; Rab; Lipid raft; Sphingomyelin; Ceramide; Biology; Pinocytosis; Vesicular transport protein; Clathrin; Glycosphingolipid; Endocytosis; Chemistry; Vesicle; Biochemistry; Signal transduction; Receptor; Glycolipid; Cholesterol; GTPase; Membrane; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106246,0.0003669481,0.0001643944,0.0002460569,0.0002571309,0.000341553,0.0001831262,0.0003237385,0.0006115215],"category_scores_gemma":[0.0002217413,0.0001144045,0.0001476629,0.0001087776,0.0002302838,0.0001958642,0.0002002213,0.0003025266,0.0003965241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006139703,"about_ca_system_score_gemma":0.000420952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002145709,"about_ca_topic_score_gemma":0.00235393,"domain_scores_codex":[0.9998891,0.000021482,0.00001109352,0.000009993127,0.00003819929,0.00003020741],"domain_scores_gemma":[0.9999423,0.000007143766,0.00001032471,0.000009573621,0.0000142161,0.00001641008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001002802,0.00001742724,0.0002377175,0.00003916607,0.00000460801,0.0002831345,0.00001344237,0.0001354534,0.9962664,0.0004644533,0.00007705203,0.002360842],"study_design_scores_gemma":[0.00004001987,0.0001001513,0.002578188,0.000007003109,0.00001792804,0.001142028,0.00003362339,0.001535841,0.990597,0.0001895999,0.003752695,0.000005943552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992554,0.002187167,0.002690171,0.0001618353,0.00002057964,0.00004024962,0.0001432215,0.0001237805,0.002078888],"genre_scores_gemma":[0.9923599,0.001679206,0.003205808,0.00003942286,0.000006843221,0.00002610253,0.000223494,0.00001997594,0.002439178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002145709,"threshold_uncertainty_score":0.004454732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03484175087733286,"score_gpt":0.2877694204625575,"score_spread":0.2529276695852246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}