{"id":"W4238712646","doi":"10.1016/j.jalz.2010.08.215","title":"P4‐156: Synthesis and Evaluation of Butyrylcholinesterase Ligands for Neuroimaging Alzheimer's Disease","year":2010,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Chemistry; Senile plaques; In vivo; Cholinesterase; Ligand (biochemistry); Enzyme; Neuroimaging; Biochemistry; Spect imaging; Alzheimer's disease; Aché; Pathology; Neuroscience; Disease; Internal medicine; Medicine; Biology; Receptor; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000239672,0.0008011151,0.000532749,0.0004660006,0.0002009158,0.0003079365,0.0006770887,0.0007150144,0.003914098],"category_scores_gemma":[0.0003603658,0.0002507468,0.0003386525,0.00029501,0.0001555435,0.0005265556,0.0003460198,0.0006611979,0.001821515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002268447,"about_ca_system_score_gemma":0.000441453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006104649,"about_ca_topic_score_gemma":0.0005428417,"domain_scores_codex":[0.9998924,0.00002228845,0.00001205592,0.00002177081,0.00002726229,0.00002428098],"domain_scores_gemma":[0.9999053,0.00001184882,0.0000146635,0.00001022461,0.00002410217,0.00003377383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003209454,0.0002924407,0.0001308054,0.0005952444,0.00004325963,0.0006874652,0.00008078202,0.001136021,0.9567924,0.001129525,0.0008286386,0.03796252],"study_design_scores_gemma":[0.0002947875,0.005328808,0.001036248,0.0001042593,0.0001117382,0.001105105,0.00003518086,0.0014501,0.9422227,0.0003869997,0.04788344,0.00004060619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.870151,0.0308298,0.052761,0.0007545765,0.000670585,0.002840353,0.002426903,0.0004697793,0.03909595],"genre_scores_gemma":[0.8728642,0.02075174,0.05985056,0.0005613911,0.0001330355,0.001472922,0.003669601,0.000169724,0.04052681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003914098,"threshold_uncertainty_score":0.01309395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05905264258299772,"score_gpt":0.3421423687839476,"score_spread":0.2830897262009499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}