{"id":"W4238846318","doi":"10.1002/ange.200603284","title":"Inhibition of siRNA Binding to a p19 Viral Suppressor of RNA Silencing by Cysteine Alkylation","year":2007,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Steacie Institute for Molecular Sciences","funders":"","keywords":"Small interfering RNA; Chemistry; RNA; Gene silencing; Molecular biology; RNA-induced transcriptional silencing; Alkylation; RNA-induced silencing complex; Cysteine; Cell biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886251,0.0003096059,0.0002035118,0.0001244136,0.0001369153,0.0001606391,0.000239264,0.0002992338,0.001602203],"category_scores_gemma":[0.0001881458,0.0001236488,0.0002348656,0.0001082341,0.0001987199,0.0001207643,0.0001751752,0.0002674119,0.0003847818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002625883,"about_ca_system_score_gemma":0.0001384986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006779278,"about_ca_topic_score_gemma":0.0008245305,"domain_scores_codex":[0.9998603,0.0000265871,0.00001308454,0.00002820278,0.00003939555,0.00003239916],"domain_scores_gemma":[0.9998922,0.00004752933,0.00002026659,0.00001178808,0.00001205897,0.00001614552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003945718,0.000008617258,0.00002114952,0.00001188426,0.000001945059,0.00001228806,0.000005507886,0.00001624473,0.9995524,0.00002264183,0.000007840709,0.0002999579],"study_design_scores_gemma":[0.000003503455,0.0001072277,0.0002949651,6.655795e-7,0.000002725227,0.00001821959,0.000002304497,0.0001504715,0.9990535,0.000005367553,0.0003602371,8.192822e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949929,0.00083238,0.002544861,0.00003641644,0.0000152822,0.00003171498,0.0001136543,0.00004362295,0.001389154],"genre_scores_gemma":[0.9934256,0.0005775281,0.002509127,0.00003965594,0.000006125907,0.00004168124,0.0004454649,0.00002422224,0.002930553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602203,"threshold_uncertainty_score":0.005359888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956381881817293,"score_gpt":0.2404373407535551,"score_spread":0.2208735219353821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}