{"id":"W4238846318","doi":"10.1002/ange.200603284","title":"Inhibition of siRNA Binding to a p19 Viral Suppressor of RNA Silencing by Cysteine Alkylation","year":2007,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Steacie Institute for Molecular Sciences","funders":"","keywords":"Small interfering RNA; Chemistry; RNA; Gene silencing; Molecular biology; RNA-induced transcriptional silencing; Alkylation; RNA-induced silencing complex; Cysteine; Cell biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177752,0.00008767893,0.0001534886,0.0000213704,0.00008901954,0.000006488653,0.00005732196,0.0000597759,0.00006655884],"category_scores_gemma":[0.00007969543,0.00004130187,0.00006052949,0.0003029611,0.00004225434,0.00009381132,0.00005616344,0.00005082663,0.000007533436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003648492,"about_ca_system_score_gemma":0.000002250134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003762649,"about_ca_topic_score_gemma":0.000202621,"domain_scores_codex":[0.9992808,0.000009056656,0.0002458094,0.000144694,0.0001519746,0.0001676548],"domain_scores_gemma":[0.9996037,0.0001062807,0.000126518,0.00003278175,0.00008782587,0.0000429076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003444962,0.00003916127,0.001693291,0.00001300227,0.00001005233,5.346968e-7,0.0002007247,0.000001736056,0.9955038,0.00002178527,0.0008282684,0.001653205],"study_design_scores_gemma":[0.00009681918,0.0002736443,0.005302689,0.00004856338,0.00001149863,0.000001042688,0.0003859251,0.000001181287,0.9932233,0.00003780622,0.0005327655,0.00008476296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958078,0.0001308359,0.00003581892,0.0001065472,0.00003967373,0.000120002,0.00006792899,0.00002704517,0.003664389],"genre_scores_gemma":[0.9995469,0.00001582179,0.0001084015,0.00003944264,0.0001012976,0.000004909695,0.00003674523,9.662261e-7,0.0001454993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003739157,"threshold_uncertainty_score":0.1684241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956381881817293,"score_gpt":0.2404373407535551,"score_spread":0.2208735219353821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}