{"id":"W4238916270","doi":"10.21203/rs.3.rs-328004/v1","title":"Evaluation of an Oral Sodium Bicarbonate Protocol for High-Dose Methotrexate Urine Alkalinization","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Foothills Medical Centre; Alberta Health Services; University of Alberta Hospital","funders":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta; University of Alberta; Johns Hopkins University; Alberta Health Services","keywords":"Sodium bicarbonate; Urine; Methotrexate; Bicarbonate; Protocol (science); Medicine; Pharmacology; Chemistry; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003304867,0.0004761125,0.001260062,0.0004538015,0.0007290404,0.001174036,0.001129201,0.0008967671,0.002929477],"category_scores_gemma":[0.007368615,0.0002180118,0.0007027186,0.0003161592,0.0005660777,0.0006063834,0.0006759765,0.001028696,0.0004350689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009636833,"about_ca_system_score_gemma":0.002725107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00218732,"about_ca_topic_score_gemma":0.001860282,"domain_scores_codex":[0.9979807,0.0007751291,0.000251169,0.0002427199,0.0006072337,0.000143181],"domain_scores_gemma":[0.9982166,0.0005568971,0.0003119589,0.0001963155,0.0003320303,0.0003861483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1743209,0.03023188,0.02041649,0.003379062,0.0008680905,0.0009885705,0.001367388,0.004801104,0.1916788,0.001620255,0.006472951,0.5638545],"study_design_scores_gemma":[0.0351353,0.4117947,0.1332371,0.001965417,0.003138574,0.002918032,0.002224373,0.03287327,0.3167784,0.002203112,0.05726802,0.0004636694],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.95727,0.003248838,0.02236333,0.001474638,0.0006091213,0.009262803,0.0004300568,0.0006817276,0.004659345],"genre_scores_gemma":[0.9508837,0.00108656,0.0420075,0.0006688761,0.0001773755,0.002942909,0.0003939755,0.00009240579,0.00174658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003304867,"threshold_uncertainty_score":0.01747805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2053897297245929,"score_gpt":0.5236204637557271,"score_spread":0.3182307340311342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}