{"id":"W4238946464","doi":"10.7287/peerj.preprints.2641","title":"Species-specific pharmacology of maximakinin, an amphibian homologue of bradykinin: putative prodrug activity at the human B<sub>2</sub> receptor and peptidase resistance in rat","year":2016,"lang":"en","type":"preprint","venue":"","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Bradykinin; Receptor; Molecular biology; Recombinant DNA; Agonist; Histamine; Radioligand; Peptide; Chemistry; Biology; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385637,0.0002406892,0.0001767293,0.0001389608,0.0001132425,0.0002369375,0.0001659867,0.0002131955,0.00173272],"category_scores_gemma":[0.0001130774,0.0001468317,0.0002728868,0.00006050201,0.0002162156,0.0001992715,0.000105356,0.0004876958,0.0003622879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001914121,"about_ca_system_score_gemma":0.000138024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003432193,"about_ca_topic_score_gemma":0.0005455712,"domain_scores_codex":[0.9999117,0.00001609722,0.000007196541,0.00001741607,0.00001132882,0.00003637409],"domain_scores_gemma":[0.9999382,0.000009897517,0.00001981637,0.000006582048,0.000005801108,0.00001963148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002479204,0.00001960602,0.0001616513,0.00001740541,0.000002578891,0.00004237188,0.00001246745,0.0000168419,0.9986967,0.00006819709,0.0000127303,0.000701557],"study_design_scores_gemma":[0.00003074891,0.001832527,0.01403018,0.000006194511,0.00003357329,0.0008165982,0.00005288484,0.0003006124,0.9807585,0.00004257545,0.002089638,0.000005966619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963349,0.001133274,0.001165111,0.00005233878,0.00001449761,0.00002412763,0.0001751897,0.00002302971,0.001077528],"genre_scores_gemma":[0.9957381,0.0007802794,0.001308734,0.00005083433,0.00001494598,0.00003337831,0.0003362655,0.00001196195,0.001725473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173272,"threshold_uncertainty_score":0.005796492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336568165529023,"score_gpt":0.2979621289680382,"score_spread":0.264596447312748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}