{"id":"W4238988136","doi":"10.21203/rs.2.17122/v1","title":"Evaluation of rapid extraction methods coupled with Recombinase polymerase amplification assay for point-of-need diagnosis of Post-kala-azar-dermal leishmaniasis","year":2019,"lang":"en","type":"preprint","venue":"Research Square","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Global Affairs Canada; Department for International Development; UNICEF; International Centre for Diarrhoeal Disease Research, Bangladesh; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Recombinase Polymerase Amplification; Visceral leishmaniasis; DNA extraction; Leishmania donovani; Leishmaniasis; Polymerase chain reaction; Biology; Molecular biology; Virology; DNA; Detection limit; Medicine; Immunology; Chromatography; Chemistry; Loop-mediated isothermal amplification; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002415115,0.001070584,0.0006804973,0.001083366,0.0002185234,0.0008475024,0.0007384334,0.001254006,0.001100636],"category_scores_gemma":[0.003134721,0.0006446071,0.0006331876,0.0005688033,0.0005795957,0.0005637761,0.0004414614,0.0006015225,0.0009017573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003326062,"about_ca_system_score_gemma":0.0003890638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000461206,"about_ca_topic_score_gemma":0.001024543,"domain_scores_codex":[0.9948437,0.001508653,0.0004553195,0.001129488,0.001818771,0.0002440129],"domain_scores_gemma":[0.99749,0.001092923,0.0006039402,0.0001222644,0.0005989096,0.00009185146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006037092,0.0004138596,0.02007399,0.0004436114,0.00006430886,0.0001377911,0.000157311,0.0007075943,0.9556971,0.0001377581,0.0002156927,0.02134741],"study_design_scores_gemma":[0.000072754,0.005138338,0.04325834,0.00008069278,0.0003152261,0.00174727,0.0002308367,0.01207653,0.9332469,0.0001465249,0.003575818,0.0001108568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9141582,0.004115387,0.0767131,0.0003354608,0.0002459802,0.0007650006,0.001214326,0.0004107116,0.002041837],"genre_scores_gemma":[0.8977078,0.001756226,0.09626585,0.0002384897,0.00008464397,0.0005260435,0.00168795,0.00004250617,0.001690529],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002415115,"threshold_uncertainty_score":0.01277256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1633258373159888,"score_gpt":0.486905906974308,"score_spread":0.3235800696583192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}