{"id":"W4238996017","doi":"10.1002/anie.200353128","title":"The Exceptional Glutathione Peroxidase‐Like Activity of Di(3‐hydroxypropyl) Selenide and the Unexpected Role of a Novel Spirodioxaselenanonane Intermediate in the Catalytic Cycle","year":2004,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Organoselenium and organotellurium chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Selenide; Catalytic cycle; Thiol; Peroxidase; Catalysis; Glutathione; Chemistry; Selenium; Glutathione peroxidase; Oxidative stress; GPX3; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479675,0.0001888464,0.0001174915,0.00009915121,0.00008497757,0.0002889746,0.0001877896,0.0002605191,0.0004221307],"category_scores_gemma":[0.00009381314,0.0001146118,0.0001152854,0.00007344475,0.0002049737,0.0003020963,0.0001801329,0.0002898263,0.0001638344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001559375,"about_ca_system_score_gemma":0.0001506757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009008226,"about_ca_topic_score_gemma":0.0001650418,"domain_scores_codex":[0.9999613,0.000006037805,0.000003601516,0.000008879984,0.00001172937,0.000008552472],"domain_scores_gemma":[0.999963,0.000004416097,0.000006989115,0.000006845788,0.00000626517,0.00001232436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003599231,0.000007228896,0.0001645112,0.0000179985,0.00000276717,0.0001043091,0.00001789048,0.00004476287,0.9969483,0.0006500351,0.00002382025,0.001982398],"study_design_scores_gemma":[0.000008972631,0.0001102813,0.0008454645,0.000001309567,0.000005137044,0.0003683267,0.00001249686,0.000290077,0.9963396,0.0003551893,0.001659912,0.000003230652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901915,0.001656383,0.006048198,0.0002277248,0.0000267301,0.00001170968,0.00005040986,0.00007013048,0.001717232],"genre_scores_gemma":[0.9955629,0.0004512632,0.002337458,0.00002666087,0.000006086672,0.000006304787,0.00007366093,0.000006386173,0.001529364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004221307,"threshold_uncertainty_score":0.001412153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02130433550803731,"score_gpt":0.3168847234098618,"score_spread":0.2955803879018245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}