{"id":"W4238996017","doi":"10.1002/anie.200353128","title":"The Exceptional Glutathione Peroxidase‐Like Activity of Di(3‐hydroxypropyl) Selenide and the Unexpected Role of a Novel Spirodioxaselenanonane Intermediate in the Catalytic Cycle","year":2004,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Organoselenium and organotellurium chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Selenide; Catalytic cycle; Thiol; Peroxidase; Catalysis; Glutathione; Chemistry; Selenium; Glutathione peroxidase; Oxidative stress; GPX3; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006849382,0.0001856507,0.0002104508,0.00005811366,0.0001716501,0.00002315031,0.0004449742,0.0001827843,0.00009855979],"category_scores_gemma":[0.0002327434,0.0001115335,0.0001093323,0.0002018389,0.0008751098,0.0001580251,0.0001042912,0.0005463561,0.000005722454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001100163,"about_ca_system_score_gemma":0.0001125383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001277126,"about_ca_topic_score_gemma":0.00007229195,"domain_scores_codex":[0.9986686,0.00009285545,0.0003987013,0.0002382129,0.0003789255,0.0002227019],"domain_scores_gemma":[0.9985532,0.0007314337,0.0003032744,0.0001907318,0.0001685349,0.00005285264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000865988,0.0005898047,0.0007285747,0.00003891024,0.0001249587,0.000004292039,0.002281607,0.0001851004,0.993277,0.000853998,0.0001956625,0.0008541538],"study_design_scores_gemma":[0.004386141,0.00004315629,0.009076392,0.00003938257,0.00007686851,0.00005272094,0.0005256287,0.0004655191,0.9824345,0.001658775,0.001120703,0.0001201863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939489,0.0004004802,0.0001698891,0.003842399,0.0005039129,0.0002698216,0.0001876425,0.00001836643,0.0006585493],"genre_scores_gemma":[0.9983436,0.0004796713,0.00002422225,0.000301046,0.0005683234,0.00006460676,0.0001308117,0.00001452693,0.00007314393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01084242,"threshold_uncertainty_score":0.4548202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02130433550803731,"score_gpt":0.3168847234098618,"score_spread":0.2955803879018245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}