{"id":"W4239169033","doi":"10.4161/pri.15900","title":"Prion-like propagation and protein misfolding","year":2011,"lang":"en","type":"article","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Alberta Heritage Foundation for Medical Research; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Prion protein; Protein folding; Prion Proteins; Computational biology; Biology; Cell biology; Medicine; Pathology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004978756,0.0004858722,0.0003191503,0.0007956136,0.0004494649,0.0009139486,0.0004147648,0.0008329941,0.0007330176],"category_scores_gemma":[0.0004694206,0.0002238191,0.0001965211,0.0004629618,0.001011596,0.001153687,0.0003347745,0.0008355528,0.0003163883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003879133,"about_ca_system_score_gemma":0.0001361199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003631198,"about_ca_topic_score_gemma":0.0003471841,"domain_scores_codex":[0.999863,0.00005074917,0.00000963427,0.00002010884,0.00003555356,0.00002087468],"domain_scores_gemma":[0.9997312,0.00009551434,0.00006841424,0.00003826611,0.00002601947,0.00004062078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001328158,0.0005797503,0.006460046,0.0009874312,0.0001086832,0.008148398,0.0007445118,0.003716415,0.7813352,0.1366804,0.005054729,0.05485623],"study_design_scores_gemma":[0.0001488966,0.001286587,0.04223109,0.0001417128,0.0002098284,0.02220852,0.0005859298,0.01636832,0.589692,0.2728803,0.05410569,0.0001410921],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6695192,0.2615114,0.03527916,0.005154345,0.0008029385,0.00006906494,0.0003734559,0.0003147782,0.02697564],"genre_scores_gemma":[0.9556366,0.03429516,0.00305303,0.0003531855,0.0003707356,0.00001659637,0.0002472893,0.00001796434,0.006009415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009139486,"threshold_uncertainty_score":0.002814472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774234913288487,"score_gpt":0.2226736590644803,"score_spread":0.2049313099315954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}