{"id":"W4239332495","doi":"10.1002/cbic.200790039","title":"Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6","year":2007,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Debrisoquine; Hydrogen peroxide; Chemistry; Cofactor; Cytochrome P450; Cumene hydroperoxide; Stereochemistry; CYP2D6; Enzyme; Biochemistry; Biocatalysis; Cytochrome; Catalysis; Reaction mechanism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001874139,0.0002308588,0.000232472,0.0001167641,0.00009853723,0.0002393715,0.0002349138,0.0001669287,0.002014453],"category_scores_gemma":[0.0003159215,0.0000955566,0.0002068889,0.0001728547,0.0001793391,0.0001538642,0.0001194223,0.0003526855,0.0006811004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002068311,"about_ca_system_score_gemma":0.0001217672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003608447,"about_ca_topic_score_gemma":0.0005146185,"domain_scores_codex":[0.9998449,0.00003041222,0.00001641154,0.00004890937,0.00003486998,0.00002443155],"domain_scores_gemma":[0.9998411,0.00003091248,0.00004536415,0.00004028811,0.00001671935,0.00002554205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002157666,0.00003531361,0.0005387195,0.00003020888,0.00001031934,0.00008368099,0.00001026086,0.0000578885,0.9947199,0.00015029,0.0001447077,0.004002971],"study_design_scores_gemma":[0.00001296901,0.0001247354,0.001497377,0.000001077493,0.00000809281,0.0003204686,0.000007414598,0.0002013377,0.994624,0.00004665008,0.003153008,0.000002932764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891367,0.001604185,0.006738892,0.0002385407,0.00007650725,0.00001539464,0.0005244572,0.0001789681,0.001486275],"genre_scores_gemma":[0.9928917,0.0005785028,0.004029411,0.0000379733,0.00001044372,0.000007789471,0.0007016882,0.00003686006,0.001705749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002014453,"threshold_uncertainty_score":0.00673902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04757041394275949,"score_gpt":0.3897087963773538,"score_spread":0.3421383824345944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}