{"id":"W4239332495","doi":"10.1002/cbic.200790039","title":"Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6","year":2007,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Debrisoquine; Hydrogen peroxide; Chemistry; Cofactor; Cytochrome P450; Cumene hydroperoxide; Stereochemistry; CYP2D6; Enzyme; Biochemistry; Biocatalysis; Cytochrome; Catalysis; Reaction mechanism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001277584,0.000335484,0.0004696894,0.0001350877,0.0001172063,0.00001312768,0.0002434027,0.0003640415,0.00009477483],"category_scores_gemma":[0.0004672719,0.0003013105,0.00008652652,0.0004276385,0.0001881854,0.00008306769,0.0001188134,0.0005428468,0.000002486546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001225713,"about_ca_system_score_gemma":0.000146743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005295307,"about_ca_topic_score_gemma":0.0001253524,"domain_scores_codex":[0.9979221,0.0001074094,0.0006028274,0.000561448,0.0001447603,0.0006615101],"domain_scores_gemma":[0.9984176,0.0005931103,0.0003045394,0.0002305992,0.0001848301,0.0002693803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005925525,0.0003771639,0.002096042,0.00009864822,0.0001721395,0.00000446889,0.0007966968,0.000002508479,0.9842276,0.000006892633,0.001436159,0.004856184],"study_design_scores_gemma":[0.006988461,0.0001948249,0.003218332,0.00001221914,0.000129853,0.00001043124,0.0001824778,0.0007691155,0.977536,0.00002016893,0.01059956,0.0003386106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959919,0.001947142,0.00005357013,0.0002559312,0.0003710223,0.0008566605,0.0002564598,0.00004993878,0.00021733],"genre_scores_gemma":[0.9977441,0.0004975091,0.0002655031,0.0003511437,0.0001097532,0.00004315398,0.00009629608,0.00004139867,0.0008511109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0091634,"threshold_uncertainty_score":0.9999439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04757041394275949,"score_gpt":0.3897087963773538,"score_spread":0.3421383824345944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}