{"id":"W4239358047","doi":"10.1097/00130832-200308000-00001","title":"The danger hypothesis applied to idiosyncratic drug reactions","year":2003,"lang":"en","type":"review","venue":"Current Opinion in Allergy and Clinical Immunology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Drug reaction; Drug development; Perspective (graphical); Medicine; Data science; Drug; Risk analysis (engineering); Computer science; Pharmacology; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008698136,0.001330182,0.001777328,0.001607272,0.0003557582,0.0009499106,0.001009689,0.001637361,0.003374476],"category_scores_gemma":[0.001797918,0.0002151817,0.0006600856,0.001606782,0.001216183,0.001862533,0.0006507678,0.002195459,0.00259844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000728904,"about_ca_system_score_gemma":0.001071798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007326116,"about_ca_topic_score_gemma":0.0006363849,"domain_scores_codex":[0.9995341,0.0001513079,0.00007177833,0.00005966054,0.0001557941,0.00002736329],"domain_scores_gemma":[0.9992722,0.0003647594,0.0001271833,0.00002475892,0.0001671993,0.00004384346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001172097,0.00005294098,0.0007607991,0.02373849,0.000140789,0.002337625,0.0001534079,0.001051482,0.002109117,0.02293318,0.06892589,0.877679],"study_design_scores_gemma":[0.00003274611,0.0001067578,0.001667313,0.006565046,0.0001400371,0.01401829,0.000186824,0.0003315973,0.0009160589,0.01621594,0.9597892,0.00003015465],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001855875,0.9935076,0.0008054412,0.0009141837,0.001493029,0.00001348629,0.00000990523,0.00001202625,0.003058796],"genre_scores_gemma":[0.002149065,0.9936751,0.0004955567,0.001022345,0.001247274,0.0000132734,0.00001585904,0.000002963576,0.001378599],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003374476,"threshold_uncertainty_score":0.01128876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1619686815355411,"score_gpt":0.4370062830361935,"score_spread":0.2750376015006524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}