{"id":"W4239369407","doi":"10.1038/s42003-018-0262-9","title":"Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters","year":2019,"lang":"en","type":"article","venue":"Communications Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta; University of Toronto; Princess Margaret Cancer Centre","funders":"Division of Materials Research; National Research Council Canada; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; National Institute of General Medical Sciences; Western Economic Diversification Canada; Alberta Glycomics Centre; University of Saskatchewan; National Science Foundation","keywords":"Transporter; Homology (biology); Biology; SUPERFAMILY; Transport protein; Biochemistry; Lipoprotein; ATP-binding cassette transporter; Membrane protein; Protein superfamily; Activator (genetics); Solute carrier family; Lipid droplet; Cell biology; Function (biology); Gene; Membrane; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002118243,0.0003831851,0.000406097,0.0001974876,0.0002983997,0.0005761835,0.000359661,0.0004042673,0.002319708],"category_scores_gemma":[0.000289451,0.0001789954,0.00028976,0.0002828732,0.0001385892,0.0001928087,0.0002684224,0.0007631723,0.0006347219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000753602,"about_ca_system_score_gemma":0.0003028045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001999721,"about_ca_topic_score_gemma":0.002061953,"domain_scores_codex":[0.9999076,0.00001392394,0.000005029603,0.00002586137,0.00002825564,0.0000193248],"domain_scores_gemma":[0.9998963,0.00002864805,0.00001989287,0.00000545234,0.00001840118,0.00003128665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002137326,0.0004880516,0.01699286,0.0007957918,0.000353941,0.003950182,0.0006763794,0.008083013,0.9298663,0.002990209,0.01236453,0.02130153],"study_design_scores_gemma":[0.00140607,0.000843373,0.1298198,0.0003472917,0.0006799746,0.01023247,0.001500974,0.1246043,0.6091462,0.003068785,0.1181479,0.0002028985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885407,0.004900701,0.001367729,0.0005402722,0.00006218733,0.00002411645,0.001647663,0.000173352,0.002743301],"genre_scores_gemma":[0.9817837,0.00166232,0.004120048,0.0002645537,0.00002227255,0.00003286512,0.00878141,0.00003507276,0.003297866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002319708,"threshold_uncertainty_score":0.007760167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236597355252194,"score_gpt":0.2398932091157552,"score_spread":0.2275272355632333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}