{"id":"W4239369407","doi":"10.1038/s42003-018-0262-9","title":"Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters","year":2019,"lang":"en","type":"article","venue":"Communications Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta; University of Toronto; Princess Margaret Cancer Centre","funders":"Division of Materials Research; National Research Council Canada; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; National Institute of General Medical Sciences; Western Economic Diversification Canada; Alberta Glycomics Centre; University of Saskatchewan; National Science Foundation","keywords":"Transporter; Homology (biology); Biology; SUPERFAMILY; Transport protein; Biochemistry; Lipoprotein; ATP-binding cassette transporter; Membrane protein; Protein superfamily; Activator (genetics); Solute carrier family; Lipid droplet; Cell biology; Function (biology); Gene; Membrane; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410156,0.0001153876,0.0002145005,0.00004111811,0.00007650759,0.000002711237,0.0006673293,0.0001825486,0.00007813756],"category_scores_gemma":[0.000004769313,0.00008160957,0.0000890954,0.00007463077,0.0006860555,0.000003131697,0.00007164423,0.0001191837,0.000001140097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004509823,"about_ca_system_score_gemma":0.00005649555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001542331,"about_ca_topic_score_gemma":0.0006605377,"domain_scores_codex":[0.9992067,0.0001562159,0.0002717262,0.0001793479,0.00004755309,0.0001384402],"domain_scores_gemma":[0.9985077,0.00002153842,0.0001486436,0.001207144,0.00009122755,0.00002374584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001607176,0.0000441244,0.024815,0.00001748072,0.00006905303,1.706336e-7,0.00017579,0.000005383117,0.9717799,0.002658023,0.0000116507,0.0002627091],"study_design_scores_gemma":[0.003185289,0.004242202,0.2473516,0.00004198142,0.000193742,0.00004887362,0.000987389,0.00002560077,0.7090847,0.0008709273,0.0334336,0.0005340421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973903,0.0006116872,0.0006705624,0.0002130807,0.00005053571,0.0002858343,0.0000714543,0.000005600874,0.0007009146],"genre_scores_gemma":[0.9942682,0.00009674931,0.0005927436,0.0000330915,0.00003707374,0.00001730248,0.004867911,0.00001260307,0.00007437355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2626951,"threshold_uncertainty_score":0.3327942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236597355252194,"score_gpt":0.2398932091157552,"score_spread":0.2275272355632333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}