{"id":"W4239460021","doi":"10.1016/s0960-894x(04)00293-8","title":"Discovery of a potent and selective $alpha;v$beta;3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Public Health Agency of Canada","keywords":"Neointima; Chemistry; Antagonist; In vivo; Integrin; Alpha (finance); BETA (programming language); Structure–activity relationship; Pharmacology; Selectivity; IC50; Stereochemistry; Receptor; In vitro; Biochemistry; Internal medicine; Stent; Surgery; Restenosis; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000193363,0.0004377263,0.0005021665,0.0003168828,0.0002423465,0.0002958804,0.0003527635,0.0003759597,0.0009090785],"category_scores_gemma":[0.0001229549,0.000232335,0.0003063713,0.0001929642,0.0001306611,0.0001684806,0.0001858261,0.0006001493,0.0003901569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002232077,"about_ca_system_score_gemma":0.0003312527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005566234,"about_ca_topic_score_gemma":0.001536946,"domain_scores_codex":[0.9999033,0.00001444823,0.000006202003,0.0000130976,0.0000200181,0.00004290428],"domain_scores_gemma":[0.9999619,0.000004943496,0.000007529467,0.000003551049,0.000007872804,0.00001426892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002326565,0.0001636971,0.0001469689,0.00006112057,0.00002114885,0.0001675674,0.00002482062,0.0001864742,0.9899737,0.000277673,0.0003768272,0.008367448],"study_design_scores_gemma":[0.0003200218,0.00259164,0.002647194,0.00001468085,0.0001262048,0.001124322,0.00002377489,0.001438626,0.9812576,0.0001447449,0.01029151,0.00001974558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691195,0.007532779,0.01518941,0.000556774,0.0001051544,0.0002495256,0.0006024062,0.0001874245,0.006457038],"genre_scores_gemma":[0.978407,0.00481333,0.009790835,0.0003876736,0.00007318088,0.0001604693,0.001122249,0.00002699918,0.005218319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009090785,"threshold_uncertainty_score":0.003041208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01048456436205575,"score_gpt":0.2472104579503408,"score_spread":0.236725893588285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}