{"id":"W4239576230","doi":"10.26434/chemrxiv.14065025","title":"Limited Hydrolysis of Polysialic Acid by Human Neuraminidase Enzymes","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre; University of Alberta","keywords":"Polysialic acid; Sialic acid; Neuraminidase; Biochemistry; Chemistry; Sialidase; Hydrolysis; Enzyme; Glycan; Glycoprotein; Cell; Neural cell adhesion molecule; Cell adhesion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003385643,0.0003958451,0.0001780585,0.00009254918,0.00007145818,0.0002331423,0.0001760557,0.0002000791,0.0005943219],"category_scores_gemma":[0.0002631643,0.0001179304,0.0001839315,0.0001113574,0.0001911342,0.0002072247,0.0002091059,0.0002726949,0.0003377688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003255404,"about_ca_system_score_gemma":0.0002676964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009547435,"about_ca_topic_score_gemma":0.0008786098,"domain_scores_codex":[0.9997867,0.0000558071,0.00001964001,0.00005677585,0.00004881644,0.00003220781],"domain_scores_gemma":[0.9998783,0.00003766114,0.00002855637,0.00002399401,0.00001708539,0.00001443829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009290269,0.000008512447,0.0001584488,0.0000260659,0.000004444244,0.0000186896,0.00001124848,0.0000533212,0.9981817,0.00007207852,0.0000150314,0.001357654],"study_design_scores_gemma":[0.000002204794,0.00006666008,0.0007344804,0.000002742404,0.000003815488,0.00004046686,0.000005006557,0.0002060637,0.9980502,0.00001366319,0.0008733357,0.000001281887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876189,0.002159958,0.00768017,0.00003794371,0.00001553516,0.00005221935,0.0003907766,0.00004684199,0.001997609],"genre_scores_gemma":[0.9844552,0.001450424,0.008262887,0.00004099329,0.000007406431,0.00005966297,0.001018398,0.00002837354,0.004676658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009547435,"threshold_uncertainty_score":0.002362013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799557449953888,"score_gpt":0.2873724973415362,"score_spread":0.2693769228419973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}