{"id":"W4239661582","doi":"10.4049/jimmunol.2000305","title":"Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"IRF7; IRF3; Ubiquitin; Transcription factor; Ubiquitin ligase; Biology; Zebrafish; Cell biology; Cancer research; Virology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009997702,0.0002488369,0.00013628,0.0001638692,0.0001777034,0.0001566055,0.0001261772,0.0002364019,0.001240372],"category_scores_gemma":[0.0000763173,0.0001111826,0.000228876,0.00005112814,0.0002793513,0.0001674877,0.0001784519,0.0003053559,0.0002470514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003445093,"about_ca_system_score_gemma":0.0002084508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265029,"about_ca_topic_score_gemma":0.002090972,"domain_scores_codex":[0.9999301,0.000008084897,0.000004628451,0.00001681537,0.00001884738,0.00002148737],"domain_scores_gemma":[0.9999291,0.000008250027,0.00002882562,0.000005741316,0.000008063358,0.00001994024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003896801,0.000003094545,0.0001989074,0.00001171867,0.000001475067,0.00002993573,0.00000494821,0.00001396397,0.9994313,0.00003526942,0.00001795039,0.0002124326],"study_design_scores_gemma":[0.0000186557,0.00008935764,0.02059317,0.000008542196,0.00001352371,0.0003082049,0.00004777804,0.001357876,0.975941,0.00007275084,0.001542552,0.000006736387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961228,0.00081518,0.001856122,0.00007861025,0.00001377739,0.00000736929,0.0001773961,0.00005396737,0.0008747749],"genre_scores_gemma":[0.9964247,0.0002047362,0.0009707166,0.00003350398,0.000002847475,0.000009291928,0.0001603588,0.00001307945,0.002180692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265029,"threshold_uncertainty_score":0.004149437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0200036534794316,"score_gpt":0.2384305203643672,"score_spread":0.2184268668849356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}