{"id":"W4239681822","doi":"10.21203/rs.3.rs-289074/v1","title":"Extracellular Mutation Induces an Allosteric Effect Across the Membrane and Hampers the Activity of MRP1 (ABCC1)","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Teva Pharmaceutical Industries","keywords":"Allosteric regulation; ATP-binding cassette transporter; ABCC1; Transporter; Extracellular; Multiple drug resistance; Biology; Biophysics; Plasma protein binding; Protein structure; ATPase; Biochemistry; Chemistry; Cell biology; Drug resistance; Genetics; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008606054,0.0002170025,0.0001483531,0.00005539466,0.0001887143,0.0001730489,0.0002527534,0.0002414974,0.001629584],"category_scores_gemma":[0.0001650502,0.0001014994,0.0001969073,0.00007895826,0.0002494481,0.0001532295,0.0002799367,0.0005544762,0.0002272773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002266057,"about_ca_system_score_gemma":0.0001503771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006483059,"about_ca_topic_score_gemma":0.0008308482,"domain_scores_codex":[0.9999303,0.00001048322,0.000006082395,0.00001519593,0.00002092173,0.00001703506],"domain_scores_gemma":[0.9999369,0.00002042889,0.00001813557,0.000007148267,0.000006349153,0.00001106499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001539379,0.00005887841,0.0008025265,0.00005548623,0.00001918409,0.0002971289,0.00002589797,0.00306565,0.9924091,0.0008425281,0.0001691863,0.002100417],"study_design_scores_gemma":[0.00006800981,0.00050899,0.005878875,0.00001821852,0.0000494856,0.0005809645,0.0001175291,0.04864034,0.9400324,0.0006033584,0.003472563,0.00002910313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971859,0.0001665788,0.001828629,0.00008023486,0.00002561072,0.000007526345,0.0000559427,0.00005104514,0.0005985434],"genre_scores_gemma":[0.9988323,0.0000639122,0.0008218093,0.00002997951,0.000002544533,0.000006117905,0.00004247932,0.0000110287,0.0001897825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001629584,"threshold_uncertainty_score":0.0054515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05114575659019208,"score_gpt":0.3949335832639294,"score_spread":0.3437878266737373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}