{"id":"W4239743462","doi":"10.1016/s2468-1253(16)30024-3","title":"Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial","year":2016,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":458,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Liver Centre; Toronto General Hospital","funders":"Gilead Sciences","keywords":"Tenofovir alafenamide; Medicine; HBeAg; Internal medicine; Clinical endpoint; Gastroenterology; Placebo; Hepatitis B virus; Entecavir; Hepatitis B; Randomized controlled trial; Pharmacology; Viral load; Virology; HBsAg; Human immunodeficiency virus (HIV); Lamivudine; Virus; Antiretroviral therapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002040393,0.001879245,0.003404913,0.0004398757,0.0004762948,0.001163485,0.0009514613,0.002112715,0.006469467],"category_scores_gemma":[0.002206169,0.0006571361,0.002637276,0.000406413,0.001228856,0.001099364,0.0003895691,0.002668828,0.0008488633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009377894,"about_ca_system_score_gemma":0.0009348806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001382832,"about_ca_topic_score_gemma":0.002584021,"domain_scores_codex":[0.9991529,0.0004892082,0.0000617875,0.0001158783,0.00005938704,0.0001207902],"domain_scores_gemma":[0.9989799,0.0004568858,0.0002006088,0.00007139998,0.00005726917,0.0002338315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9870105,0.000998874,0.0001573941,0.0009273333,0.001111986,0.0000308494,0.00003596212,0.0001508113,0.001243119,0.00008991966,0.0003265642,0.007916681],"study_design_scores_gemma":[0.9835958,0.01459166,0.0005189894,0.00005348206,0.0004828155,0.0000225342,0.00001641579,0.000137373,0.0001716575,0.0001269194,0.0002727206,0.000009537441],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687182,0.02166564,0.0009156889,0.001209493,0.001447801,0.002354104,0.001009202,0.0001307262,0.002549251],"genre_scores_gemma":[0.986592,0.006053088,0.001112854,0.0008373906,0.0004538209,0.0018785,0.0005577288,0.00001962365,0.002494997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006469467,"threshold_uncertainty_score":0.02164251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05185355057010008,"score_gpt":0.3419290628250715,"score_spread":0.2900755122549714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}