{"id":"W4239743462","doi":"10.1016/s2468-1253(16)30024-3","title":"Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial","year":2016,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":458,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Liver Centre; Toronto General Hospital","funders":"Gilead Sciences","keywords":"Tenofovir alafenamide; Medicine; HBeAg; Internal medicine; Clinical endpoint; Gastroenterology; Placebo; Hepatitis B virus; Entecavir; Hepatitis B; Randomized controlled trial; Pharmacology; Viral load; Virology; HBsAg; Human immunodeficiency virus (HIV); Lamivudine; Virus; Antiretroviral therapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007443446,0.0007130225,0.00248234,0.0002146703,0.0005907779,0.00002421217,0.0004055117,0.0003606428,0.0001312777],"category_scores_gemma":[0.0001564973,0.0003750213,0.000793632,0.000223296,0.001762908,0.0001407416,0.0001606283,0.0003614108,0.00007383444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008701016,"about_ca_system_score_gemma":0.000436443,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.008761002,"about_ca_topic_score_gemma":0.1221691,"domain_scores_codex":[0.9954803,0.0005894931,0.001253502,0.0008932623,0.000319408,0.001464058],"domain_scores_gemma":[0.9955627,0.001857084,0.0007540268,0.001225314,0.0003929637,0.0002079296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6541549,0.0013398,0.3305179,0.0000522822,0.002508779,0.00007347023,0.0003088633,0.000005156339,0.002354166,0.00006987026,0.001294811,0.00731993],"study_design_scores_gemma":[0.8816202,0.04985364,0.04925364,0.00008476122,0.002167721,0.0002343023,0.0000135803,0.0006702277,0.002499144,0.00008918803,0.01323436,0.0002792304],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694621,0.0007963394,0.008253405,0.01027133,0.002908053,0.007545581,0.0004828954,0.0001213416,0.0001589404],"genre_scores_gemma":[0.9782316,0.01288183,0.0001053796,0.0008170945,0.002424071,0.005150536,0.00007844429,0.00007619766,0.0002348627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2812643,"threshold_uncertainty_score":0.9998702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05185355057010008,"score_gpt":0.3419290628250715,"score_spread":0.2900755122549714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}