{"id":"W4239756280","doi":"10.1158/1538-7445.sabcs18-ct043","title":"Abstract CT043: Outcomes among patients (pts) with metastatic nonsquamous NSCLC with liver metastases or brain metastases treated with pembrolizumab (pembro) plus pemetrexed-platinum: Results from the KEYNOTE-189 study","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Hôpital Charles-Le Moyne","funders":"","keywords":"Pemetrexed; Medicine; Carboplatin; Internal medicine; Placebo; Oncology; Lung cancer; Cisplatin; Clinical endpoint; Pembrolizumab; Randomization; Progression-free survival; Nausea; Randomized controlled trial; Chemotherapy; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"design_other","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001452174,0.0007114377,0.001163005,0.0003456965,0.0002916497,0.0006339541,0.0008888155,0.0009782531,0.003086744],"category_scores_gemma":[0.001529035,0.0003054602,0.002197966,0.001084002,0.0004409397,0.0006852373,0.0004683564,0.001321497,0.0004759344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009111019,"about_ca_system_score_gemma":0.0009765141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002748402,"about_ca_topic_score_gemma":0.004126642,"domain_scores_codex":[0.9992174,0.000437156,0.00006560887,0.0001177698,0.00009489195,0.00006709067],"domain_scores_gemma":[0.9981995,0.0002773797,0.0008082897,0.0001623721,0.0001416313,0.0004108525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7398856,0.002756661,0.2190797,0.0009259816,0.006408261,0.0003114024,0.00009991191,0.00143951,0.007074878,0.00009224106,0.00384526,0.01808052],"study_design_scores_gemma":[0.1856934,0.09142937,0.7050776,0.0001591874,0.008528734,0.0009732705,0.0001053582,0.001593519,0.002781694,0.0002339078,0.0033466,0.00007732618],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883254,0.002228945,0.0002220081,0.0001859,0.00003461033,0.0003313676,0.007864158,0.00002641722,0.0007812489],"genre_scores_gemma":[0.9876634,0.0005320394,0.0002458354,0.0002264925,0.00009094911,0.0002882165,0.01042542,0.000007384016,0.0005203412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003086744,"threshold_uncertainty_score":0.01032621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1571907416247102,"score_gpt":0.4093837855418637,"score_spread":0.2521930439171535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}