{"id":"W4239761756","doi":"10.26434/chemrxiv.12296180.v1","title":"SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2","year":2020,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; National Institutes of Health; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Novartis Pharma; North Carolina Biotechnology Center; Pfizer","keywords":"Phenotype; Small molecule; Chemical library; Function (biology); Kinase; Cell biology; Computational biology; Chemistry; Biology; Cancer research; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002075644,0.0003571205,0.0002658834,0.00001914751,0.0002791073,0.00009096709,0.0006783206,0.0004289103,0.0000246095],"category_scores_gemma":[0.0003255762,0.000229935,0.000380972,0.0001067515,0.0001959578,0.000002143581,0.0006823705,0.0004881234,0.00001115412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004685037,"about_ca_system_score_gemma":0.0002278613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001083884,"about_ca_topic_score_gemma":0.00001218483,"domain_scores_codex":[0.9984371,0.00004108126,0.0002923008,0.0007125256,0.0001845787,0.0003323988],"domain_scores_gemma":[0.9987047,0.00006780097,0.0002092975,0.0007434769,0.0001799613,0.00009472043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004404291,0.000137128,0.0003340625,0.0006234724,0.0006628311,0.000007022481,0.0003758848,0.0004723181,0.9405093,0.001303569,0.05234981,0.002784201],"study_design_scores_gemma":[0.0005314904,0.00006348604,0.000368595,0.00006311292,0.0001237686,0.000006819329,0.00003458585,0.001417222,0.8598556,0.001857689,0.1353306,0.0003470402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5541529,0.03731998,0.2792084,0.1028105,0.002666977,0.01950712,0.0003009253,0.000492936,0.003540267],"genre_scores_gemma":[0.9939194,0.0001391259,0.0009754139,0.001394995,0.001817261,0.001098576,0.0003401388,0.00006313051,0.0002519237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4397666,"threshold_uncertainty_score":0.9376475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02019833092122106,"score_gpt":0.2546606037444554,"score_spread":0.2344622728232344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}