{"id":"W4239999531","doi":"10.12688/f1000research.6110.2","title":"Virtual screen for repurposing approved and experimental drugs for candidate inhibitors of EBOLA virus infection","year":2015,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services","funders":"Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja","keywords":"Ebola virus; Repurposing; DrugBank; Drug repositioning; Medicine; Virtual screening; Ebolavirus; Virology; Virus; Pharmacology; Drug discovery; Bioinformatics; Biology; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005668825,0.001255971,0.001556712,0.001481267,0.0004863604,0.001216479,0.0007444949,0.0005406958,0.006345821],"category_scores_gemma":[0.001334806,0.0003498331,0.001140045,0.001000314,0.0002190382,0.0004373789,0.0008006145,0.0005323392,0.00184715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004644135,"about_ca_system_score_gemma":0.0008273523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005151156,"about_ca_topic_score_gemma":0.0009423582,"domain_scores_codex":[0.9995949,0.0001152636,0.00002978306,0.00006957363,0.0001348422,0.00005563572],"domain_scores_gemma":[0.999719,0.0001461209,0.00002540253,0.0000293371,0.00003783454,0.00004238893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.005470139,0.002577868,0.009952885,0.0044159,0.001687194,0.002828652,0.0002397896,0.1000464,0.6225061,0.009527263,0.04322179,0.197526],"study_design_scores_gemma":[0.001889391,0.005173551,0.0182178,0.0002679002,0.001976922,0.002376246,0.0002577588,0.2620522,0.5950819,0.007347852,0.105036,0.0003224341],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8777494,0.006991533,0.04322879,0.001533836,0.0002678196,0.001581662,0.03164801,0.008210185,0.02878868],"genre_scores_gemma":[0.8641414,0.004512256,0.08236244,0.0007265021,0.00006906816,0.001164494,0.0370413,0.0004833455,0.009499247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006345821,"threshold_uncertainty_score":0.02122885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06573058750326084,"score_gpt":0.4072274883254633,"score_spread":0.3414969008222025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}