{"id":"W4240000737","doi":"10.1023/a:1023495626568","title":"Regulation of cytosolic phospholipase A2, cyclooxygenase-1 and -2 expression by PMA, TNFα, LPS and M-CSF in human monocytes and macrophages","year":2003,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"U937 cell; Phorbol; Lipopolysaccharide; Arachidonic acid; Eicosanoid; Prostaglandin E2; Tumor necrosis factor alpha; Phospholipase A2; Macrophage; Chemistry; Prostaglandin; Monocyte; Biology; Biochemistry; Enzyme; Endocrinology; Protein kinase C; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002561876,0.0002764643,0.0003093427,0.0003464699,0.0003141875,0.0004860267,0.000110369,0.0002616746,0.001080591],"category_scores_gemma":[0.0002576026,0.0002252069,0.0003326274,0.0003322902,0.0002742802,0.0003463223,0.0002085062,0.0004097219,0.0002994322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003318416,"about_ca_system_score_gemma":0.000301817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001300149,"about_ca_topic_score_gemma":0.001462361,"domain_scores_codex":[0.9997969,0.00004190794,0.00002481538,0.00002247663,0.00002582565,0.00008808252],"domain_scores_gemma":[0.9998714,0.00003667311,0.00001852831,0.00001917244,0.00002726586,0.00002696306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00449697,0.00008162334,0.001639646,0.0001201662,0.00001036689,0.000377548,0.0001962699,0.0000776571,0.9906199,0.0002019121,0.00009979076,0.002077996],"study_design_scores_gemma":[0.0003734168,0.001358614,0.07074735,0.00003696668,0.00007372828,0.0009242331,0.0006440061,0.001267518,0.9206313,0.0003452662,0.003577948,0.00001964149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950069,0.002652975,0.0006710559,0.0001256819,0.00004611123,0.00002784003,0.0005367897,0.00001396246,0.0009186152],"genre_scores_gemma":[0.9941959,0.001520957,0.0007008546,0.00007136053,0.00004829057,0.00008561762,0.0006112205,0.000004988769,0.002760701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300149,"threshold_uncertainty_score":0.003614962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003062717218252917,"score_gpt":0.2087449774408298,"score_spread":0.2056822602225769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}