{"id":"W4240000737","doi":"10.1023/a:1023495626568","title":"Regulation of cytosolic phospholipase A2, cyclooxygenase-1 and -2 expression by PMA, TNFα, LPS and M-CSF in human monocytes and macrophages","year":2003,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"U937 cell; Phorbol; Lipopolysaccharide; Arachidonic acid; Eicosanoid; Prostaglandin E2; Tumor necrosis factor alpha; Phospholipase A2; Macrophage; Chemistry; Prostaglandin; Monocyte; Biology; Biochemistry; Enzyme; Endocrinology; Protein kinase C; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836381,0.0001900619,0.0002729916,0.00004800936,0.00006465807,0.00001903422,0.00002551771,0.0001785787,0.0000136147],"category_scores_gemma":[0.00005428884,0.0001784507,0.00002906688,0.0000685268,0.0001553564,0.0000334085,0.00003927273,0.0001234982,2.23948e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001439004,"about_ca_system_score_gemma":0.00001954873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002293743,"about_ca_topic_score_gemma":4.588475e-7,"domain_scores_codex":[0.9990644,0.00005024302,0.0002157826,0.0003313248,0.0001355336,0.0002027195],"domain_scores_gemma":[0.99949,0.0000204907,0.0000761827,0.0001926224,0.00002616072,0.0001945569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005260067,0.00004993398,0.007703765,0.0005551279,0.00001417055,0.00009116926,0.00009552284,3.76471e-7,0.9909424,0.00004218223,0.00008321657,0.0003695023],"study_design_scores_gemma":[0.001817625,0.00008374286,0.002160992,0.0001872834,0.00004821534,0.00006027073,0.0001069003,0.00004840019,0.9950898,0.0001232733,0.0001057474,0.0001677984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980931,0.01848974,0.00007801116,0.00003010803,0.00001389531,0.000190131,0.000008302427,0.00001155038,0.0002472267],"genre_scores_gemma":[0.9993845,0.0001740674,0.0001695005,0.00005555003,0.0000177735,0.0000120152,0.00004963443,0.00002105726,0.0001159327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01845344,"threshold_uncertainty_score":0.7277009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003062717218252917,"score_gpt":0.2087449774408298,"score_spread":0.2056822602225769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}