{"id":"W4240062892","doi":"10.1042/bj3630019","title":"Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt","year":2002,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children; Canadian Institutes of Health Research","funders":"","keywords":"Protein kinase B; Platelet-derived growth factor receptor; Tensin; Wortmannin; Phosphorylation; Signal transduction; Platelet-derived growth factor; PTEN; Biology; Cell biology; PI3K/AKT/mTOR pathway; Molecular biology; Growth factor; Chemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008152819,0.0003489705,0.000118723,0.0001551286,0.0001674511,0.000299132,0.0001162381,0.0001713763,0.001187705],"category_scores_gemma":[0.00006643154,0.0001213586,0.0001567103,0.0001283093,0.0001896543,0.0001520075,0.0001420349,0.0004087324,0.0004809884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003881331,"about_ca_system_score_gemma":0.0002894138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007358112,"about_ca_topic_score_gemma":0.0008002322,"domain_scores_codex":[0.999917,0.00001251626,0.000006642774,0.00001199806,0.00003036028,0.00002132725],"domain_scores_gemma":[0.9999554,0.000007222302,0.0000145603,0.000005323487,0.000005207906,0.00001224705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007889717,0.00002091721,0.00009625423,0.00003419704,0.00000254215,0.0000571814,0.000006852576,0.00005964849,0.9979665,0.0004285561,0.00004827792,0.001200309],"study_design_scores_gemma":[0.00001992288,0.0001554597,0.002514026,0.000005320898,0.00001406079,0.0002882996,0.00001152118,0.001143915,0.9913998,0.0001218052,0.00432218,0.000003676985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870591,0.002210068,0.005129446,0.0001977099,0.00005653281,0.00004106962,0.0005818058,0.0001308776,0.004593357],"genre_scores_gemma":[0.9916683,0.001879096,0.002572042,0.00004306556,0.000009936613,0.00002604966,0.0005726747,0.00001407189,0.003214826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187705,"threshold_uncertainty_score":0.003973305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0254172696969887,"score_gpt":0.2456850165634528,"score_spread":0.2202677468664641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}