{"id":"W4240080893","doi":"10.1200/jco.2012.30.18_suppl.lba10008","title":"Randomized phase III trial of regorafenib in patients (pts) with metastatic and/or unresectable gastrointestinal stromal tumor (GIST) progressing despite prior treatment with at least imatinib (IM) and sunitinib (SU): GRID trial.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Medicine; Regorafenib; Internal medicine; Clinical endpoint; Hazard ratio; GiST; Randomization; Randomized controlled trial; Placebo; Gastroenterology; Surgery; Confidence interval; Cancer; Colorectal cancer; Pathology; Stromal cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00149906,0.001715559,0.002318842,0.0003106265,0.0003604333,0.0008521821,0.0009214187,0.001474297,0.009933276],"category_scores_gemma":[0.001467183,0.0006432352,0.001029018,0.0003781269,0.001102985,0.0007917428,0.0005156713,0.002742998,0.001999924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008526024,"about_ca_system_score_gemma":0.0015767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001382412,"about_ca_topic_score_gemma":0.004105722,"domain_scores_codex":[0.9995919,0.0002232479,0.00001802967,0.00007632865,0.00002375545,0.0000668298],"domain_scores_gemma":[0.9992704,0.000114622,0.0001903324,0.00007466152,0.00004023533,0.0003096636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9726685,0.004684112,0.0009297419,0.00043653,0.0004791656,0.00008861137,0.00005252859,0.0005477203,0.002777009,0.000189405,0.003935436,0.01321136],"study_design_scores_gemma":[0.9805083,0.01731097,0.0007008856,0.00001159859,0.00009686504,0.00004408266,0.000009901401,0.0001926579,0.0001445038,0.0001335857,0.000840794,0.000005995643],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556078,0.005105362,0.001874437,0.002757304,0.001328597,0.0166338,0.008224233,0.0006719242,0.007796516],"genre_scores_gemma":[0.9586813,0.002774611,0.003575504,0.003621795,0.0004019412,0.01726108,0.005466481,0.00007317087,0.008144116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009933276,"threshold_uncertainty_score":0.03323007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1390128879229256,"score_gpt":0.4586018462701245,"score_spread":0.3195889583471989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}