{"id":"W4240082975","doi":"10.1093/neuonc/noy148.977","title":"RBTT-08. EORTC 1709/CCTG CE.8: A PHASE III TRIAL OF MARIZOMIB IN COMBINATION WITH STANDARD TEMOZOLOMIDE-BASED RADIOCHEMOTHERAPY VERSUS STANDARD TEMOZOLOMIDE-BASED RADIOCHEMOTHERAPY ALONE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Temozolomide; Medicine; Oncology; Dacarbazine; Internal medicine; Radiation therapy; Population; Chemotherapy; Quality of life (healthcare); Phases of clinical research; Randomized controlled trial; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002211494,0.002198437,0.002166865,0.0007647546,0.0004030636,0.0008298678,0.001398087,0.001772803,0.007246753],"category_scores_gemma":[0.001130727,0.0006752515,0.001479038,0.0006225322,0.0009178455,0.0008464496,0.0003561808,0.00317481,0.001779105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001330983,"about_ca_system_score_gemma":0.002227576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00400992,"about_ca_topic_score_gemma":0.01262209,"domain_scores_codex":[0.9994331,0.000316016,0.00002466832,0.00006302034,0.00004850321,0.0001147171],"domain_scores_gemma":[0.9994057,0.00007914956,0.0001445262,0.00003655365,0.00003513728,0.0002988646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9088687,0.02380377,0.001597372,0.000706372,0.0005951216,0.00008336484,0.00007149694,0.0009697768,0.01259732,0.0004386904,0.006430253,0.0438377],"study_design_scores_gemma":[0.8705077,0.1227932,0.002921608,0.00003591415,0.0002807876,0.000066768,0.000021176,0.0005997155,0.0008483165,0.0001489474,0.001756029,0.00001977966],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681768,0.004814987,0.0009285135,0.001628701,0.0006971709,0.01208028,0.004438655,0.0004447763,0.00678998],"genre_scores_gemma":[0.9565995,0.004494534,0.004190011,0.00284365,0.0006230323,0.01329084,0.007109005,0.0001310153,0.01071845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007246753,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139060830624282,"score_gpt":0.2860805503967322,"score_spread":0.2746899420904894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}