{"id":"W4240089891","doi":"10.3410/f.737301604.793572143","title":"Faculty Opinions recommendation of Mitochondrial Dysfunction Combined with High Calcium Load Leads to Impaired Antioxidant Defense Underlying the Selective Loss of Nigral Dopaminergic Neurons.","year":2020,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Universität zu Köln; Deutsche Forschungsgemeinschaft","keywords":"Substantia nigra; Mitochondrion; Membrane potential; Inner mitochondrial membrane; Oxidative stress; Cell biology; Programmed cell death; Chemistry; Dopaminergic; Biology; Calcium; Neuroprotection; Dopamine; Neuroscience; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001023861,0.0006429827,0.0006351767,0.001263957,0.001235688,0.004021857,0.00111422,0.003960682,0.4534733],"category_scores_gemma":[0.003234072,0.0003366575,0.0006886593,0.001005701,0.0007534408,0.001217248,0.001334342,0.002340483,0.2308449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001742861,"about_ca_system_score_gemma":0.003317605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003750572,"about_ca_topic_score_gemma":0.008646797,"domain_scores_codex":[0.9990356,0.00006357563,0.00006450971,0.0001684986,0.0005198796,0.0001479331],"domain_scores_gemma":[0.9968071,0.0001515437,0.0002242217,0.0001393607,0.001621512,0.001056204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001517895,0.00007881504,0.0007422988,0.0006176725,0.00002743136,0.000308634,0.00006773545,0.0001030282,0.005539108,0.002492169,0.8735937,0.1162776],"study_design_scores_gemma":[0.00002327303,0.00004084458,0.0008967078,0.0002042872,0.00001298004,0.0001571126,0.0001008397,0.00008838102,0.0009944933,0.0009459301,0.9965237,0.00001138884],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.00558229,0.02779769,0.003347689,0.1619382,0.1457317,0.0004247472,0.008196612,0.001318517,0.6456627],"genre_scores_gemma":[0.01634124,0.01965095,0.001449125,0.01500808,0.02955449,0.00009645618,0.003433192,0.0003365514,0.9141299],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4534733,"threshold_uncertainty_score":0.779554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02906265056629176,"score_gpt":0.3141519478349392,"score_spread":0.2850892972686474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}