{"id":"W4240203552","doi":"10.1200/jco.2007.25.18_suppl.6515","title":"Evolution of the randomized controlled trial (RCT) in oncology over three decades","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Meta-analysis and systematic reviews","field":"Decision Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Medicine; Randomized controlled trial; Clinical endpoint; Internal medicine; Hazard ratio; Sample size determination; Oncology; Breast cancer; Lung cancer; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7120605,0.002077207,0.01618405,0.01654792,0.002476943,0.02358331,0.007301965,0.02095254,0.004582978],"category_scores_gemma":[0.7900264,0.004310214,0.006425487,0.02265449,0.03206827,0.0257756,0.01291947,0.015414,0.001070199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0368035,"about_ca_system_score_gemma":0.0413987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004320842,"about_ca_topic_score_gemma":0.00316425,"domain_scores_codex":[0.2184571,0.6280609,0.07963352,0.0251112,0.04639972,0.002337555],"domain_scores_gemma":[0.07431707,0.8160356,0.0441351,0.02862758,0.03291819,0.003966524],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01048066,0.0006485382,0.01764353,0.09199114,0.008538307,0.0005173288,0.004589455,0.003921511,0.001224078,0.2169246,0.02794983,0.615571],"study_design_scores_gemma":[0.01417424,0.009266454,0.02679331,0.2638277,0.007686984,0.002785364,0.003111727,0.009445106,0.002340212,0.2708059,0.3887601,0.001002926],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.007410828,0.8083785,0.03297615,0.1294962,0.01161191,0.002368988,0.0005439442,0.0002386712,0.006974847],"genre_scores_gemma":[0.2073935,0.3952079,0.2062892,0.1486227,0.01995837,0.01840237,0.0009635107,0.0007338054,0.0024287],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2879395,"threshold_uncertainty_score":0.3550807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7350757916366921,"score_gpt":0.6509098452543743,"score_spread":0.08416594638231778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}