{"id":"W4240311355","doi":"10.1111/aos.13972_341","title":"The effect of estrogen and dihydrotestosterone on hyperosmolarity‐induced expression and production of IL‐1<i>β</i>, TNF‐<i>α</i> and IL‐8 through MAPK pathway in human corneal epithelial cells","year":2018,"lang":"en","type":"article","venue":"Acta Ophthalmologica","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"MAPK/ERK pathway; Estrogen; Tumor necrosis factor alpha; Dihydrotestosterone; Endocrinology; Biology; Internal medicine; Medicine; Cell biology; Signal transduction; Hormone; Androgen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004364635,0.0002043529,0.0004334464,0.00004140448,0.000159357,0.00001480783,0.00008093989,0.0001678642,0.000008200888],"category_scores_gemma":[0.0001391675,0.0001138092,0.00004131236,0.00009316292,0.0003473729,0.0000980694,0.0001167619,0.0002275526,0.000001214482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001477378,"about_ca_system_score_gemma":0.0000166989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001143431,"about_ca_topic_score_gemma":0.000004139919,"domain_scores_codex":[0.9987014,0.0002188089,0.0002854136,0.0003798832,0.0001892407,0.0002252576],"domain_scores_gemma":[0.9991518,0.0002086383,0.000170318,0.0003587005,0.00004719579,0.00006335974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008460098,0.0001004417,0.05293493,0.00009513369,0.00002173138,0.00003916086,0.0002906848,1.369056e-7,0.9436762,0.00002734187,0.000006855443,0.001961415],"study_design_scores_gemma":[0.001359817,0.009037957,0.06791317,0.0001872383,0.00003843699,0.0001329317,0.00007559032,0.000003666779,0.9207595,0.0001865113,0.0001967224,0.000108461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983313,0.0002901515,6.574997e-7,0.0002629304,0.0001401676,0.0007029601,0.00001431612,0.00001335095,0.0002441663],"genre_scores_gemma":[0.9995549,0.0001171271,0.0001047731,0.00002977946,0.00008792456,0.00002244587,0.00000548251,0.00001605946,0.0000614503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02291667,"threshold_uncertainty_score":0.4641006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252057582461672,"score_gpt":0.2708661950246218,"score_spread":0.2483456192000051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}