{"id":"W4240520511","doi":"10.21203/rs.3.rs-60074/v2","title":"Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-Associated Markers in 3xtg-AD Mice ","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Immunosuppression; Epigenetics; Disease; Alzheimer's disease; Medicine; Neuroscience; Differential (mechanical device); Immunology; Psychology; Biology; Internal medicine; Genetics; Physics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941872,0.0008186346,0.0004611562,0.0008492286,0.0002383394,0.0003122241,0.000345831,0.0004706887,0.001851985],"category_scores_gemma":[0.00009527599,0.0001968668,0.0003517935,0.0002341577,0.0004122116,0.0003051074,0.0002426501,0.001197939,0.0004971424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003335426,"about_ca_system_score_gemma":0.0002017499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007615689,"about_ca_topic_score_gemma":0.001605699,"domain_scores_codex":[0.9997523,0.00002720298,0.00002528874,0.0000667991,0.00004976374,0.00007861878],"domain_scores_gemma":[0.9996015,0.00003221428,0.0001253391,0.00004936037,0.00003324962,0.0001582754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009106463,0.0002778378,0.0006196022,0.00003089316,0.00001074529,0.0001207654,0.00003875591,0.00004303796,0.9962484,0.00006449153,0.00007422888,0.001560594],"study_design_scores_gemma":[0.0001062125,0.003487787,0.02560762,0.00002722251,0.00007937136,0.0004910398,0.0001189659,0.0007498968,0.9669961,0.0001238183,0.002192002,0.00001995657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973519,0.000595323,0.0004916708,0.00006273229,0.00002436366,0.00002218159,0.0006884329,0.00009073995,0.0006725983],"genre_scores_gemma":[0.9919896,0.0006075993,0.001609314,0.0001081417,0.00002408631,0.0001275124,0.001071112,0.0000720977,0.004390487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001851985,"threshold_uncertainty_score":0.006195486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08926353322244047,"score_gpt":0.3868165522261424,"score_spread":0.2975530190037019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}