{"id":"W4240552905","doi":"10.1016/j.jalz.2017.06.1642","title":"[P3–425]: ELEVATED CSF LEVELS OF NEUROFILAMENT LIGHT CHAIN IS ASSOCIATED WITH GRAY MATTER NEURODEGENERATION IN BOTH HUMANS AND TRANSGENIC RAT MODEL OF ALZHEIMER's DISEASE","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill Genome Centre; Douglas Mental Health University Institute; Douglas College; McGill University","funders":"","keywords":"Neurodegeneration; Pathology; Parahippocampal gyrus; Cerebrospinal fluid; Internal medicine; Medicine; Precuneus; Superior frontal gyrus; Atrophy; Endocrinology; Oncology; Neuroscience; Psychology; Disease; Magnetic resonance imaging; Temporal lobe; Radiology; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005190382,0.0003180322,0.0003685689,0.00008622812,0.0002762145,0.00004942315,0.0003217788,0.00008132684,0.000683901],"category_scores_gemma":[0.00001906691,0.0003018554,0.00007163853,0.0001090476,0.0003275558,0.0005385418,0.000172495,0.0001836832,0.00002943585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002329887,"about_ca_system_score_gemma":0.00003563518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002849337,"about_ca_topic_score_gemma":0.0003860968,"domain_scores_codex":[0.9974459,0.0002196336,0.000594401,0.0007436504,0.0005269895,0.0004693826],"domain_scores_gemma":[0.9985275,0.00002918166,0.0005179522,0.0007074958,0.00001693726,0.0002009616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001930435,0.0007845585,0.5493976,0.00002234512,0.001913812,0.00002713784,0.002516309,0.006208366,0.4321466,0.00004949763,0.0005396589,0.006200982],"study_design_scores_gemma":[0.001428314,0.0001445166,0.8229539,0.00006089752,0.003172227,6.523148e-7,0.00002418609,0.01707791,0.1545817,0.0001138688,0.00005914575,0.0003826828],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957914,0.001030197,0.0006581486,0.00111087,0.00005546939,0.0008737877,0.00008913187,0.00001597555,0.0003750228],"genre_scores_gemma":[0.9984583,0.00009330296,0.0003683645,0.0009175528,0.00001035044,0.00005514443,0.00002570433,0.00005124454,0.00002008878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2775649,"threshold_uncertainty_score":0.9999434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03388388233203539,"score_gpt":0.2569075900383426,"score_spread":0.2230237077063072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}