{"id":"W4240552905","doi":"10.1016/j.jalz.2017.06.1642","title":"[P3–425]: ELEVATED CSF LEVELS OF NEUROFILAMENT LIGHT CHAIN IS ASSOCIATED WITH GRAY MATTER NEURODEGENERATION IN BOTH HUMANS AND TRANSGENIC RAT MODEL OF ALZHEIMER's DISEASE","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill Genome Centre; Douglas Mental Health University Institute; Douglas College; McGill University","funders":"","keywords":"Neurodegeneration; Pathology; Parahippocampal gyrus; Cerebrospinal fluid; Internal medicine; Medicine; Precuneus; Superior frontal gyrus; Atrophy; Endocrinology; Oncology; Neuroscience; Psychology; Disease; Magnetic resonance imaging; Temporal lobe; Radiology; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971388,0.0006515821,0.0003276155,0.0005725801,0.0004808038,0.0002432282,0.0002798295,0.0005698326,0.007998657],"category_scores_gemma":[0.0001666019,0.000187624,0.0003698751,0.0004881104,0.0004040142,0.0002626913,0.000313941,0.0005633357,0.001484008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001788824,"about_ca_system_score_gemma":0.0002742896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001876375,"about_ca_topic_score_gemma":0.001384478,"domain_scores_codex":[0.9998651,0.00001491152,0.00001456695,0.00005445189,0.00002572716,0.00002523153],"domain_scores_gemma":[0.999858,0.000007278814,0.00005350955,0.00001419716,0.00002154243,0.0000454011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00674814,0.0008251908,0.02136969,0.0004024957,0.0001743371,0.009323359,0.0003023819,0.0001646876,0.9248419,0.0009559896,0.004461073,0.03043077],"study_design_scores_gemma":[0.0008315573,0.0123007,0.6135182,0.0001890273,0.0004622709,0.06161049,0.0005839078,0.001990106,0.2600988,0.003482919,0.04482363,0.0001083761],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985489,0.0008393223,0.00303359,0.0003377287,0.0001160835,0.0001150179,0.002026603,0.0002276102,0.007815052],"genre_scores_gemma":[0.9805431,0.0006092676,0.00254576,0.0004335017,0.00006576985,0.0002276509,0.002560954,0.0001285185,0.01288545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007998657,"threshold_uncertainty_score":0.02675813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03388388233203539,"score_gpt":0.2569075900383426,"score_spread":0.2230237077063072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}