{"id":"W4240622323","doi":"10.2337/figshare.12933737.v1","title":"Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 Ideas: European Research Council; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; NIHR Oxford Biomedical Research Centre; National Institutes of Health; Diabetesforeningen; Cotswold Foundation; Academy of Finland; Terveyden ja hyvinvoinnin laitos; American Heart Association; Novo Nordisk Fonden; National Institute of General Medical Sciences; Diabetesliitto; National Human Genome Research Institute; Danmarks Frie Forskningsfond; Augustinus Fonden; Emil Aaltosen Säätiö; Medical Research Council; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Paavo Nurmen Säätiö; Centre for Medical Systems Biology; Li Ka Shing Foundation; Novo Nordisk; Murdoch University; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; University of Notre Dame; Novo Nordisk Foundation Center for Basic Metabolic Research; Tays; National Health and Medical Research Council; Suomen Kulttuurirahasto; Edith Cowan University; Sydäntutkimussäätiö; Münchner Zentrum für Gesundheitswissenschaften; Curtin University of Technology; National Institute on Minority Health and Health Disparities; European Commission; Diabetes UK; Canadian Institutes of Health Research; National Heart, Lung, and Blood Institute; Bundesministerium für Gesundheit; Yrjö Jahnssonin Säätiö; National Institute for Health and Care Research; Foundation for Cardiovascular Research; National Center for Advancing Translational Sciences; Hjerteforeningen; Tampereen Tuberkuloosisäätiö; Kela; ZonMw; Raine Medical Research Foundation; Johns Hopkins University; Russian Foundation for Basic Research; Bundesministerium für Bildung und Forschung; Women and Infants Research Foundation; Wake Forest University; Children's Hospital of Philadelphia; Wellcome Trust; Juho Vainion Säätiö","keywords":"Leptin; Missense mutation; Endocrinology; Internal medicine; Allele; Obesity; Biology; Exome; Exome sequencing; Genetics; Medicine; Mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004174443,0.0005591058,0.0004655416,0.0008264631,0.0002744134,0.0005404616,0.0002857772,0.0003729401,0.00337193],"category_scores_gemma":[0.0009591239,0.0002728077,0.0003838006,0.0009631325,0.0005185711,0.0002751865,0.0003571856,0.0005271002,0.0003945527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843449,"about_ca_system_score_gemma":0.0001822545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001139417,"about_ca_topic_score_gemma":0.001378709,"domain_scores_codex":[0.9996347,0.00008247147,0.00003873301,0.0001084942,0.00009953348,0.00003603506],"domain_scores_gemma":[0.9993768,0.0001724041,0.0003065401,0.00004835011,0.00004307753,0.00005274266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000950417,0.00008325916,0.09894565,0.0002458944,0.0003117692,0.000899093,0.0001536742,0.0004350424,0.8781987,0.0005518143,0.0002701299,0.01895456],"study_design_scores_gemma":[0.0001056768,0.0008774655,0.6829113,0.00008190231,0.0003172283,0.003959561,0.0002243934,0.002147042,0.302407,0.001427528,0.00549474,0.00004618438],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870852,0.003168645,0.005948477,0.0002264203,0.00003676625,0.00002548742,0.001602366,0.00009675075,0.001810015],"genre_scores_gemma":[0.9935662,0.00131092,0.003556706,0.0001485694,0.00002187718,0.00003925459,0.0005851475,0.00004956035,0.00072179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00337193,"threshold_uncertainty_score":0.01128024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1022334816930364,"score_gpt":0.3285786896896403,"score_spread":0.2263452079966039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}