{"id":"W4240625033","doi":"10.20944/preprints201909.0043.v3","title":"An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients","year":2020,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"La Trobe University; Judith Jane Mason and Harold Stannett Williams Memorial Foundation","keywords":"Mitochondrion; Basal metabolic rate; Oxidative stress; Biology; Internal medicine; Mitochondrial DNA; ATP synthase; Endocrinology; Mitochondrial disease; Cell biology; Biochemistry; Medicine; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002605804,0.0005972983,0.001130199,0.0003771783,0.0001066958,0.0000535446,0.0004642381,0.0007362241,0.002486524],"category_scores_gemma":[0.0003463177,0.0005938951,0.000196863,0.0004735577,0.0002358575,0.0001497761,0.001159532,0.001216763,0.0003716097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000568782,"about_ca_system_score_gemma":0.0006857699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002542591,"about_ca_topic_score_gemma":0.00002603224,"domain_scores_codex":[0.9953225,0.0003689876,0.0009985003,0.001809982,0.0008681757,0.0006318743],"domain_scores_gemma":[0.9974722,0.00009190947,0.0003134191,0.001323405,0.0002870154,0.0005120222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003471253,0.000983317,0.8164575,0.001344412,0.0004156562,0.00008812553,0.001436827,0.0002168481,0.1750583,0.00001818631,0.00009314292,0.000416434],"study_design_scores_gemma":[0.008639977,0.0005229806,0.9597661,0.0009796902,0.0002022155,0.000009178999,0.0001195747,0.02444201,0.004211278,0.0005280752,0.00007495465,0.0005039481],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959368,0.0002857812,0.0001481129,0.0003220734,0.0006148233,0.001985989,0.0001014317,0.0002663508,0.0003386956],"genre_scores_gemma":[0.9959208,0.0001346539,0.0002317577,0.00003660512,0.0001251285,0.0001280722,0.00322376,0.0000941445,0.0001051261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.170847,"threshold_uncertainty_score":0.9996513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09280293871134775,"score_gpt":0.3514022501314168,"score_spread":0.258599311420069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}