{"id":"W4240674910","doi":"10.3410/f.737742310.793580830","title":"Faculty Opinions recommendation of FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer.","year":2020,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"PTEN; Protein kinase B; Cancer research; Cell growth; Cell cycle progression; Apoptosis; Cell cycle; PI3K/AKT/mTOR pathway; Prostate cancer; Cell; Signal transduction; Prostate; Chemistry; Cancer; Cell biology; Medicine; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001718147,0.001302827,0.001280704,0.00217849,0.0006491316,0.001847584,0.001909118,0.002034343,0.04624069],"category_scores_gemma":[0.009972599,0.0004140447,0.002028181,0.003374594,0.0002899338,0.0008848782,0.001269416,0.001382527,0.0348002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001652734,"about_ca_system_score_gemma":0.002894483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02598318,"about_ca_topic_score_gemma":0.07383454,"domain_scores_codex":[0.9984245,0.0003279194,0.0002111424,0.0003810355,0.0004779691,0.0001773668],"domain_scores_gemma":[0.9961362,0.001188203,0.0007525273,0.000486393,0.001088909,0.0003477265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002706081,0.00003029504,0.005264572,0.00182245,0.0002038069,0.00003113595,0.00001538993,0.0002507386,0.0002796413,0.0002315193,0.9844112,0.007188621],"study_design_scores_gemma":[0.0010048,0.00007998155,0.03845265,0.001149224,0.0005805414,0.0002649523,0.00006605948,0.000841141,0.001157475,0.0008953182,0.9554462,0.00006159224],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.00050591,0.0005661672,0.00006191322,0.0004092458,0.00006738574,0.00001799665,0.9969915,0.000148319,0.001231573],"genre_scores_gemma":[0.001896347,0.00037409,0.0003505031,0.0003257203,0.00003121259,0.00007474126,0.995114,0.00003942286,0.001793912],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.04624069,"threshold_uncertainty_score":0.1546905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03063305660807397,"score_gpt":0.349478761663327,"score_spread":0.3188457050552531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}