{"id":"W4240675030","doi":"10.3892/ijo.32.6.1343","title":"Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells","year":2008,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health Research Institute; Vancouver Coastal Health","funders":"Canadian Dermatology Foundation; Dermatology Foundation","keywords":"Irinotecan; Biology; Gene; Amplicon; Camptothecin; Genetics; Drug resistance; Topoisomerase; Cancer; DNA; Colorectal cancer; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870181,0.00008588282,0.0001827006,0.0001376691,0.00002870912,0.00001092274,0.0003373968,0.00009795113,0.00002188654],"category_scores_gemma":[0.00002567286,0.00008197813,0.0001275035,0.00003817569,0.00005063259,0.00000577934,0.00004718163,0.00005279195,0.000001874966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507715,"about_ca_system_score_gemma":0.000317582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002705544,"about_ca_topic_score_gemma":0.0005029128,"domain_scores_codex":[0.9991912,0.00003664837,0.0003677612,0.0001358606,0.0001317226,0.0001367595],"domain_scores_gemma":[0.9992548,0.00002714004,0.0002973309,0.00009019498,0.0002817835,0.00004871741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008812155,0.0001000834,0.0008695626,0.000002431373,0.0002034468,0.0000998251,0.00009558727,0.0001391032,0.9948156,0.00006252703,0.001081855,0.001648766],"study_design_scores_gemma":[0.002042557,0.0007339049,0.00514524,0.00001067643,0.00002523441,0.0002586743,0.00003286043,0.00002724097,0.8280647,0.0006776509,0.1628748,0.0001064644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916234,0.001455261,0.004942372,0.0004981127,0.001091421,0.00007982667,0.00004009631,0.000001522215,0.0002679914],"genre_scores_gemma":[0.992987,0.001337809,0.004148889,0.0004346631,0.0005911287,0.000007941027,0.0000242679,0.00001242377,0.0004559277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1667509,"threshold_uncertainty_score":0.3342972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0439017291606517,"score_gpt":0.3723956697071283,"score_spread":0.3284939405464766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}