{"id":"W4240675030","doi":"10.3892/ijo.32.6.1343","title":"Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells","year":2008,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health Research Institute; Vancouver Coastal Health","funders":"Canadian Dermatology Foundation; Dermatology Foundation","keywords":"Irinotecan; Biology; Gene; Amplicon; Camptothecin; Genetics; Drug resistance; Topoisomerase; Cancer; DNA; Colorectal cancer; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000350332,0.0001452242,0.000163113,0.0004525571,0.0001090667,0.0001640146,0.0001040586,0.0001485334,0.001529292],"category_scores_gemma":[0.0000881757,0.0001027949,0.0002076739,0.0003498332,0.00007288158,0.0000534818,0.0001101278,0.0002136208,0.0003545499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001425461,"about_ca_system_score_gemma":0.0001027339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00064023,"about_ca_topic_score_gemma":0.001102193,"domain_scores_codex":[0.9999543,0.000002712809,0.000002806391,0.00001611723,0.00001294329,0.00001097627],"domain_scores_gemma":[0.9999484,0.00001078379,0.00001402826,0.000006423702,0.000008519937,0.0000118665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007225305,0.00001038528,0.002023655,0.0000223543,0.00000731559,0.0001297996,0.00001763835,0.0000464089,0.996061,0.00002620346,0.00002197419,0.001560995],"study_design_scores_gemma":[0.00003729347,0.0004994186,0.4658898,0.00001554112,0.000137703,0.002010662,0.0001765126,0.002275193,0.5224794,0.0001690663,0.006297476,0.00001190329],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948977,0.0006807783,0.001662078,0.0000357543,0.000007855675,0.00002572392,0.001816975,0.00005217005,0.0008210762],"genre_scores_gemma":[0.9899895,0.0005094243,0.002462937,0.00005376137,0.000005664311,0.00004194158,0.005084129,0.0000168154,0.001835794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529292,"threshold_uncertainty_score":0.005116045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0439017291606517,"score_gpt":0.3723956697071283,"score_spread":0.3284939405464766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}