{"id":"W4240735956","doi":"10.1200/jco.2015.33.15_suppl.tps1102","title":"Phase 3 randomized, placebo-controlled trial of carboplatin (C) and paclitaxel (P) with/without veliparib (ABT-888) in HER2-<i>BRCA</i>-associated locally advanced or metastatic breast cancer (BC).","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame","funders":"","keywords":"Veliparib; Medicine; PARP inhibitor; Carboplatin; Internal medicine; Metastatic breast cancer; Oncology; Cancer; Placebo; Chemotherapy; Phases of clinical research; BRCA mutation; Breast cancer; Olaparib; Pathology; Cisplatin; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002545786,0.002998631,0.003639523,0.0006341396,0.0009470211,0.001874649,0.001626519,0.003152326,0.01305032],"category_scores_gemma":[0.002222078,0.001213945,0.002422384,0.0006556654,0.001951839,0.002086949,0.0005995352,0.006235063,0.002982717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001383709,"about_ca_system_score_gemma":0.002346692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001511758,"about_ca_topic_score_gemma":0.003838353,"domain_scores_codex":[0.999146,0.0003718446,0.00004279817,0.0002098615,0.00006564191,0.000163882],"domain_scores_gemma":[0.998602,0.0002855423,0.000334894,0.0001489258,0.0001131499,0.0005156461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.984665,0.008066916,0.0002087856,0.0002559395,0.0003778164,0.0000295513,0.00003234285,0.000146749,0.001368422,0.00007888241,0.001121833,0.003647785],"study_design_scores_gemma":[0.97374,0.02468441,0.0004837434,0.00001701125,0.0001279132,0.00002093493,0.00001148209,0.000187374,0.00014465,0.0001558592,0.0004164131,0.00001008688],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.940616,0.006209488,0.001833127,0.002714628,0.002653956,0.03228264,0.006239288,0.0006638393,0.006787043],"genre_scores_gemma":[0.9433246,0.002994848,0.003837138,0.004922646,0.001012024,0.03195122,0.004203795,0.0001190429,0.0076347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01305032,"threshold_uncertainty_score":0.04365766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1113354754180309,"score_gpt":0.487240631562581,"score_spread":0.3759051561445501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}