{"id":"W4240755449","doi":"10.21203/rs.3.rs-76625/v1","title":"Synthesis of DOTA-Pyridine Chelates for 64Cu Coordination and Radiolabeling of αMSH Peptide","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Simon Fraser University; Occupational Cancer Research Centre; BC Cancer Agency; TRIUMF","funders":"Natural Sciences and Engineering Research Council of Canada; TRIUMF","keywords":"DOTA; Chelation; Pyridine; Chemistry; Peptide; Combinatorial chemistry; Stereochemistry; Medicinal chemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002787282,0.0003953326,0.0003797135,0.0002691685,0.0003695564,0.0002389234,0.0005430101,0.0005217288,0.003202792],"category_scores_gemma":[0.0003098684,0.0003278849,0.0002141226,0.0003623884,0.0001663154,0.0002009394,0.0003132698,0.0004668736,0.001405065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006221884,"about_ca_system_score_gemma":0.0004581825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027515,"about_ca_topic_score_gemma":0.002020607,"domain_scores_codex":[0.9998373,0.00002187404,0.00001425169,0.00004264515,0.00004466468,0.00003919423],"domain_scores_gemma":[0.999886,0.0000216116,0.00001881353,0.00002405867,0.00002486101,0.00002448485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001249653,0.00002911191,0.00005524248,0.0002129709,0.00001196528,0.0001604636,0.00007592967,0.0006104551,0.9917321,0.0008105249,0.0003061355,0.005870171],"study_design_scores_gemma":[0.00001985873,0.00009533738,0.0002680485,0.000005074727,0.000007998854,0.0001381693,0.000008307868,0.0006351781,0.9925867,0.0000688358,0.006158363,0.000008122634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8792366,0.004937053,0.09016737,0.0003753769,0.0002085228,0.001101528,0.00292806,0.001008257,0.02003722],"genre_scores_gemma":[0.9047049,0.002898613,0.07166391,0.0001791266,0.0000395171,0.0007046012,0.00197701,0.0001574125,0.01767497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003202792,"threshold_uncertainty_score":0.01071441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1342140641026577,"score_gpt":0.4561792102409123,"score_spread":0.3219651461382546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}