{"id":"W4240756220","doi":"10.1093/jcag/gwab002.016","title":"A17 EFFICACY AND SAFETY OF FILGOTINIB AS MAINTENANCE THERAPY FOR PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS: RESULTS FROM THE PHASE 2B/3 SELECTION STUDY","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Maintenance therapy; Ulcerative colitis; Adverse effect; Gastroenterology; Placebo; Surrogate endpoint; Phases of clinical research; Clinical trial; Surgery; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002312589,0.000477557,0.001011108,0.0002038615,0.0002585324,0.0006450529,0.0003785657,0.0006464919,0.004175953],"category_scores_gemma":[0.001354962,0.0001937116,0.001130518,0.0002870439,0.00037657,0.0003995188,0.0002376213,0.001318213,0.0005770367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004297243,"about_ca_system_score_gemma":0.0008572727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007027531,"about_ca_topic_score_gemma":0.001537949,"domain_scores_codex":[0.999366,0.0003839098,0.0000433934,0.00005768175,0.00007871576,0.00007032724],"domain_scores_gemma":[0.9991437,0.00019831,0.0002940424,0.00006132961,0.00008095479,0.0002215555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.736854,0.01130669,0.01977981,0.0009816776,0.001772623,0.0002159822,0.0001746874,0.0009005777,0.02868675,0.0001692051,0.007077802,0.1920803],"study_design_scores_gemma":[0.5219038,0.378659,0.08167224,0.0001747083,0.002069459,0.0005147366,0.000110768,0.001422918,0.004669158,0.0003032506,0.008457655,0.00004231312],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881989,0.00546432,0.0003902595,0.0006758028,0.00006183022,0.001058038,0.001934922,0.00007156743,0.002144349],"genre_scores_gemma":[0.9908636,0.002011009,0.0008970608,0.001038401,0.0001676092,0.000776537,0.002802567,0.00002010578,0.001422943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004175953,"threshold_uncertainty_score":0.01396996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006315934716379065,"score_gpt":0.237924100712657,"score_spread":0.2316081659962779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}