{"id":"W4241004874","doi":"10.1158/1538-7445.sabcs18-4805","title":"Abstract 4805: Cannabinoid WIN 55,212-2 induces endoplasmic reticulum stress in prostate cancer cells through CB<sub>1</sub>and CB2receptors","year":2019,"lang":"en","type":"article","venue":"Experimental and Molecular Therapeutics","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"DU145; Cannabinoid receptor; AM251; Cannabinoid; Cannabinoid receptor type 2; Unfolded protein response; Cannabinoid Receptor Agonists; Endoplasmic reticulum; Receptor; Apoptosis; Chemistry; Cancer cell; Prostate cancer; Cancer research; Cell biology; Endocrinology; Internal medicine; Biology; Cancer; Medicine; Antagonist; LNCaP; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008653331,0.000462986,0.0004199809,0.0002558864,0.0002422913,0.0002532196,0.0002269986,0.0002308219,0.004046851],"category_scores_gemma":[0.00006337425,0.0001074872,0.0003350744,0.0003304623,0.00013907,0.0001882659,0.0001633665,0.0006373576,0.0008039108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003873947,"about_ca_system_score_gemma":0.0004596417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002432169,"about_ca_topic_score_gemma":0.003017686,"domain_scores_codex":[0.9998645,0.00001450961,0.00001216316,0.00001711204,0.00004383804,0.00004787104],"domain_scores_gemma":[0.9999683,0.000003532481,0.000006066672,0.000003693661,0.000006342163,0.00001203867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001055082,0.0002382779,0.000340107,0.0002153698,0.00002284275,0.0002825882,0.00002341208,0.0000972159,0.9911801,0.0002254683,0.0007367085,0.005582863],"study_design_scores_gemma":[0.0001539665,0.002054134,0.01316811,0.00001935513,0.00006425724,0.000883798,0.00006657564,0.0009021555,0.9736046,0.0000921856,0.008978872,0.0000119699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784418,0.008269762,0.001973317,0.0005297589,0.000279313,0.00009831718,0.001865245,0.0002615231,0.008280882],"genre_scores_gemma":[0.9704639,0.004403278,0.003345317,0.0004112105,0.00007362585,0.0001196759,0.003162696,0.00002815524,0.01799222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004046851,"threshold_uncertainty_score":0.01353806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006574682594756684,"score_gpt":0.2490389973122925,"score_spread":0.2424643147175358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}