{"id":"W4241004874","doi":"10.1158/1538-7445.sabcs18-4805","title":"Abstract 4805: Cannabinoid WIN 55,212-2 induces endoplasmic reticulum stress in prostate cancer cells through CB<sub>1</sub>and CB2receptors","year":2019,"lang":"en","type":"article","venue":"Experimental and Molecular Therapeutics","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"DU145; Cannabinoid receptor; AM251; Cannabinoid; Cannabinoid receptor type 2; Unfolded protein response; Cannabinoid Receptor Agonists; Endoplasmic reticulum; Receptor; Apoptosis; Chemistry; Cancer cell; Prostate cancer; Cancer research; Cell biology; Endocrinology; Internal medicine; Biology; Cancer; Medicine; Antagonist; LNCaP; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006114665,0.0003709469,0.0002693461,0.00004838447,0.00007621539,0.00007594057,0.0001468409,0.0001706175,0.00003060628],"category_scores_gemma":[0.000003535632,0.0003453091,0.00008797177,0.00008382622,0.0001932657,0.00002015914,0.0001584395,0.0001794162,0.000009971125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002991703,"about_ca_system_score_gemma":0.00007996053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002327823,"about_ca_topic_score_gemma":0.0000479667,"domain_scores_codex":[0.9983469,0.00006495779,0.0002950498,0.000633987,0.000213869,0.0004452693],"domain_scores_gemma":[0.9993979,0.000009255299,0.0001121259,0.0002909133,0.00003668381,0.0001531046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001681405,0.0002046007,0.006001836,0.00006537506,0.00008582136,0.00003000125,0.0006714054,0.00007758279,0.9916834,0.00006774694,0.00007355404,0.0008705942],"study_design_scores_gemma":[0.001555614,0.0002101143,0.001483442,0.00007726672,0.00002913935,0.00001123795,0.001255671,0.00004453645,0.9926398,0.00004259879,0.002205312,0.000445298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823056,0.01595034,0.000006527273,0.0001562208,0.0002912223,0.0005444073,0.00009875171,0.00001615351,0.0006307391],"genre_scores_gemma":[0.9951125,0.003713773,0.00007133169,0.0007142533,0.00005644031,0.0001055902,0.00008946658,0.00005485282,0.00008179936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01280686,"threshold_uncertainty_score":0.9998999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006574682594756684,"score_gpt":0.2490389973122925,"score_spread":0.2424643147175358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}