{"id":"W4241035150","doi":"10.1016/j.atherosclerosis.2017.06.057","title":"Safety and efficacy of evinacumab, a monoclonal antibody to ANGPTL3, in patients with homozygous familial hypercholesterolemia: a single-arm, open-label, proof-of-concept study","year":2017,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Familial hypercholesterolemia; PCSK9; Medicine; Internal medicine; Antibody; Monoclonal antibody; Endocrinology; Gastroenterology; Pharmacology; Cholesterol; LDL receptor; Immunology; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001991534,0.001360562,0.003174894,0.0003247886,0.0004246981,0.001068947,0.0006482061,0.00172853,0.002162214],"category_scores_gemma":[0.001247534,0.0005907349,0.002128164,0.0002396265,0.001266018,0.001292142,0.0003014366,0.003104107,0.0005302454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007264211,"about_ca_system_score_gemma":0.0008479232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002759387,"about_ca_topic_score_gemma":0.0005433505,"domain_scores_codex":[0.9993672,0.0002723965,0.00004465032,0.0001236844,0.00007637229,0.000115754],"domain_scores_gemma":[0.9990833,0.0002506151,0.0002127847,0.0001064531,0.00006397059,0.0002829009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9148461,0.01715725,0.002408145,0.0006418671,0.001822781,0.0001512219,0.0001104669,0.000517957,0.02264476,0.0001597525,0.0007675376,0.03877221],"study_design_scores_gemma":[0.5781949,0.3971542,0.01318887,0.00007359848,0.002332327,0.0002815727,0.00007846825,0.001415552,0.004910353,0.000353038,0.001950092,0.00006702407],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929355,0.00395938,0.0009764823,0.0002916451,0.0001750117,0.0005174695,0.0003374932,0.00006247952,0.0007445381],"genre_scores_gemma":[0.9945446,0.001707543,0.0009719441,0.0005224269,0.0002245303,0.0006600609,0.0004912774,0.0000182812,0.0008591574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003174894,"threshold_uncertainty_score":0.01053238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03983609954716808,"score_gpt":0.3105564692434334,"score_spread":0.2707203696962653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}