{"id":"W4241051173","doi":"10.1093/ibd/zaa010.023","title":"P066 GB004, A NOVEL GUT-TARGETED PROLYL HYDROXYLASE INHIBITOR FOR INFLAMMATORY BOWEL DISEASE: FIRST-IN-HUMAN, MUTLIPLE-DOSE STUDY IN HEALTHY SUBJECTS WITH GUT BIOPSIES","year":2020,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Pharmacokinetics; Placebo; Inflammatory bowel disease; Adverse effect; Gastroenterology; Ulcerative colitis; Hypoxia (environmental); Internal medicine; Pharmacology; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001621433,0.001319092,0.001998758,0.0004860638,0.0006354767,0.000631112,0.000607444,0.001280311,0.002496854],"category_scores_gemma":[0.000652043,0.0005942435,0.0008716452,0.0003414165,0.001171619,0.0007742975,0.0003479477,0.001982837,0.0006058539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006815465,"about_ca_system_score_gemma":0.001046972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001321194,"about_ca_topic_score_gemma":0.002676961,"domain_scores_codex":[0.999485,0.0002162774,0.00002686549,0.0001092477,0.00006375824,0.00009883785],"domain_scores_gemma":[0.9993679,0.0001013285,0.000113134,0.00005718616,0.00006668089,0.0002936907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.548246,0.1310773,0.009440581,0.001363964,0.0009244559,0.0009626803,0.0003500021,0.0007122377,0.2354272,0.0001385425,0.001842738,0.0695143],"study_design_scores_gemma":[0.0484259,0.9203789,0.01817713,0.00001666046,0.0003737094,0.0003441942,0.00008093518,0.0003216155,0.01022327,0.00004336654,0.001591152,0.00002327881],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943026,0.002152358,0.0006997496,0.0001304727,0.00006416431,0.001431075,0.000431664,0.0000774475,0.0007105674],"genre_scores_gemma":[0.9921862,0.001485311,0.001390136,0.0004432963,0.0001500518,0.001003892,0.0006622223,0.00001822873,0.002660677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002496854,"threshold_uncertainty_score":0.008575082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193474422287489,"score_gpt":0.2515452714816225,"score_spread":0.2396105272587476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}