{"id":"W4241052313","doi":"10.12688/wellcomeopenres.16458.1","title":"MethylDetectR: a software for methylation-based health profiling","year":2020,"lang":"en","type":"preprint","venue":"Wellcome Open Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Institute of Genetics; National Institutes of Health; Centre for Cognitive Ageing and Cognitive Epidemiology; Alzheimer’s Research UK; University of Queensland; University of Edinburgh; Dementias Platform UK; Age UK; Scottish Government; Scottish Funding Council; Wellcome Trust","keywords":"Profiling (computer programming); Software; Methylation; Computational biology; Computer science; Biology; Operating system; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002506412,0.001492346,0.001065147,0.001804805,0.0005137591,0.001231661,0.00173603,0.001438495,0.07614011],"category_scores_gemma":[0.006073465,0.001368316,0.001297801,0.0009744323,0.0004449937,0.001346861,0.002438124,0.001883474,0.02880964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007089816,"about_ca_system_score_gemma":0.001132973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002992275,"about_ca_topic_score_gemma":0.004028324,"domain_scores_codex":[0.9990208,0.0001807696,0.00008727851,0.0002975365,0.0003384888,0.00007506977],"domain_scores_gemma":[0.9977182,0.001309824,0.0002728066,0.0002951361,0.000260123,0.000143944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003964981,0.0001878584,0.01971691,0.002910638,0.0008710639,0.0009164876,0.001223916,0.006344672,0.04792154,0.007766489,0.6324583,0.2757172],"study_design_scores_gemma":[0.001392201,0.0005499496,0.03395622,0.0005748072,0.0004981398,0.001509807,0.0002188683,0.07954795,0.09975371,0.03393926,0.7474411,0.0006180464],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"software","genre_gemma":"software","genre_scores_codex":[0.007795104,0.0007254496,0.1921679,0.0006682767,0.0002969014,0.000547282,0.1070448,0.6816508,0.009103392],"genre_scores_gemma":[0.1098306,0.00156416,0.4865271,0.004040224,0.0003257203,0.005373696,0.2144572,0.1397987,0.0380827],"genre_candidate":"software","genre_consensus":"software","teacher_disagreement_score":0.07614011,"threshold_uncertainty_score":0.254714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2263201545463757,"score_gpt":0.4593537792161789,"score_spread":0.2330336246698031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}