{"id":"W4241090182","doi":"10.1007/978-1-0716-0771-8","title":"Gapmers","year":2020,"lang":"en","type":"book","venue":"Methods in molecular biology","topic":"Synthesis and properties of polymers","field":"Materials Science","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"RNase H; RNase P; Gene knockdown; Oligonucleotide; RNA; Biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001109143,0.0003050944,0.0006641873,0.0001338874,0.00003109158,0.00002235827,0.0006174483,0.0005593792,0.001773239],"category_scores_gemma":[0.0005075803,0.0002609514,0.0001737264,0.00006511946,0.0002968775,0.00001629762,0.0002442088,0.0003384933,0.000361303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009027651,"about_ca_system_score_gemma":0.0002238996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003393382,"about_ca_topic_score_gemma":0.000003272518,"domain_scores_codex":[0.9971296,0.001338358,0.0004066458,0.0006472207,0.00009848427,0.0003796789],"domain_scores_gemma":[0.9990054,0.0002893203,0.0001679111,0.0004246529,0.0000219686,0.00009069573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002344656,0.00000643665,0.00000383965,0.00003478118,0.00001765907,0.0000477494,0.00006638231,0.000002788792,0.9592037,0.004725212,0.002736222,0.03313178],"study_design_scores_gemma":[0.0001073329,0.00008516182,0.000001045782,0.00004019337,0.00002432475,0.000005055843,0.0000104912,0.00001319653,0.529461,0.01284541,0.4571049,0.0003019084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.00008474199,0.01272614,0.3555912,0.001074928,0.002056381,0.0003894326,0.00005253662,0.0001162532,0.6279084],"genre_scores_gemma":[0.00001761544,0.0001488439,0.9053063,0.002647068,0.0002026834,0.00004667651,0.00003607867,0.00008264766,0.09151204],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.5497152,"threshold_uncertainty_score":0.9999843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04037874303849328,"score_gpt":0.3720625439473326,"score_spread":0.3316838009088394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}