{"id":"W4241172318","doi":"10.21203/rs.2.469/v2","title":"Genetic basis for prediction of non-responders to dietary plant sterol intervention (GenePredict-PS): a study protocol for a double-blind, placebo-controlled, randomized two-period crossover study","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Mitacs; University of Manitoba","keywords":"Double blind; Crossover study; Placebo; Crossover; Protocol (science); Randomized controlled trial; Period (music); Medicine; Intervention (counseling); Internal medicine; Computer science; Artificial intelligence; Psychiatry; Physics; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02640199,0.005048139,0.007464468,0.001981074,0.002996704,0.001703361,0.002768528,0.00710019,0.02443711],"category_scores_gemma":[0.0207194,0.002538716,0.00294139,0.001843731,0.004044192,0.001894178,0.001560844,0.004813449,0.006521118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002065292,"about_ca_system_score_gemma":0.007838745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008638563,"about_ca_topic_score_gemma":0.001249483,"domain_scores_codex":[0.9816328,0.01089997,0.001684006,0.002161792,0.001898437,0.001723028],"domain_scores_gemma":[0.9872211,0.003396928,0.002890166,0.002394871,0.002218037,0.001879019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9348281,0.04392112,0.001186096,0.001374187,0.0004442114,0.0001048409,0.0001981376,0.0009488433,0.003513938,0.0009349733,0.002224311,0.01032126],"study_design_scores_gemma":[0.8481425,0.1384998,0.003451953,0.0002216978,0.0003069111,0.00003552618,0.00004570256,0.001532489,0.001056205,0.0008434402,0.005791291,0.00007243553],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.03100736,0.0001930862,0.003522775,0.0002499984,0.0004566956,0.9625036,0.001006458,0.0001498969,0.0009100918],"genre_scores_gemma":[0.01910322,0.0001294876,0.00468326,0.0002242534,0.0001697324,0.9746308,0.000237941,0.00001336563,0.0008080087],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02640199,"threshold_uncertainty_score":0.1396287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.150437888544659,"score_gpt":0.4682808590631965,"score_spread":0.3178429705185375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}