{"id":"W4241201441","doi":"10.1093/jcag/gwy008.113","title":"A112 EARLY USE OF THERAPEUTIC DRUG MONITORING TO INDIVIDUALIZE INFLIXIMAB THERAPY IN PAEDIATRIC IBD: A MULTICENTRE PROSPECTIVE COHORT STUDY","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Microscopic Colitis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Manitoba; University of Ottawa; University of Calgary; Children's Hospital of Eastern Ontario; Memorial University of Newfoundland; McMaster Children's Hospital; Dalhousie University; BC Children's Hospital; SickKids Foundation","funders":"","keywords":"Medicine; Infliximab; Therapeutic drug monitoring; Trough level; Dosing; Maintenance therapy; Regimen; Internal medicine; Cohort; Pharmacokinetics; Pediatrics; Disease; Chemotherapy; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001010441,0.0001196817,0.0005170802,0.0005253645,0.00005091409,0.00001785532,0.0002146667,0.00008277204,0.00003470231],"category_scores_gemma":[0.0005507381,0.00009602771,0.0001218714,0.0003232152,0.00004862099,0.00009651025,0.00003821704,0.0003280702,0.000001874876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001745259,"about_ca_system_score_gemma":0.0004257109,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02354659,"about_ca_topic_score_gemma":0.3157575,"domain_scores_codex":[0.9979714,0.0004392334,0.0006807991,0.0001302935,0.0004367268,0.0003415423],"domain_scores_gemma":[0.9977503,0.0001237118,0.0009714534,0.0002083468,0.000758515,0.0001877107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005646729,0.0002239541,0.9908845,0.000005784061,0.0004037586,0.000008638543,0.007050673,0.00001003172,0.0004017536,0.000001947416,0.0002800775,0.0001642261],"study_design_scores_gemma":[0.004493039,0.002326523,0.992134,0.00006273839,0.0001248022,0.00001334838,0.0003573321,0.000003894197,0.0003105567,0.00001360929,0.0001220805,0.00003810143],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962105,0.00002687501,0.000003737568,0.002153669,0.0005495959,0.001015537,0.00001903768,0.000002558438,0.00001847444],"genre_scores_gemma":[0.9988827,0.0000152929,0.0001902638,0.0004901316,0.0002334893,0.000009847861,4.467114e-7,0.00001460769,0.0001632477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2922109,"threshold_uncertainty_score":0.9829557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486485926721872,"score_gpt":0.2713705418720208,"score_spread":0.2565056826048021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}